| Gene Symbol | TFRC |
| Full Name | Transferrin Receptor 1 |
| Aliases | CD71, TFR1 |
| Chromosome | 3q29 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Mechanism of Action | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Druggability | Medium (0.47) |
| Clinical Stage | Approved |
| Molecular Weight | 190 kDa |
| Amino Acids | 660 aa |
| Pathways | Akt, Autophagy, Blood-Brain Barrier, Ferroptosis, Pi3K |
| UniProt ID | P02786 |
| NCBI Gene ID | 7037 |
| Ensembl ID | ENSG00000072274 |
| GeneCards | TFRC |
| Human Protein Atlas | TFRC |
| Associated Diseases | ALS, ALZHEIMER, Atherosclerosis, Diabetes, Inflammation |
| Known Drugs/Compounds | Antisense Oligonucleotides, Adeno-Associated Virus, resveratrol, rapamycin |
| Interactions | SLC7A11, P38, GPX4, ACSL4, GCLC, JUN |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Blood-Brain Barrier SPM Shuttle System |
| KG Connections | 380 knowledge graph edges |
| Databases | GeneCardsHPASTRING |