Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NSD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NSD3 |
| Full Name | Nuclear Receptor Binding SET Domain Protein 3 |
| Chromosome | 8p11.23 |
| Protein Type | Transferase |
| Function | encodes a histone lysine methyltransferase of the nuclear receptor SET domain (NSD) family that catalyzes mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2). |
| Amino Acids | 1437 aa |
| Pathways | Epigenetic |
| UniProt ID | [Q9BZ95](https://www.uniprot.org/uniprot/Q9BZ95) |
| Ensembl ID | ENSG00000147548 |
| GeneCards | NSD3 |
| Human Protein Atlas | NSD3 |
| SET domain | Catalytic methyltransferase domain for H3K36 methylation |
| PWWP domain | Chromatin reader module that recognizes H3K36me marks and mediates chromatin targeting |
| PHD fingers (2x) | Zinc finger domains that bind histone tails and mediate protein–protein interactions |
| Nuclear receptor interaction domain | Enables interactions with nuclear hormone receptors and transcription factor complexes |
| Associated Diseases | neurodegeneration |
| Interactions | STAT3, MYC, PPP1CB, HK2 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NSD3["<b>NSD3</b>"]
PPP1CB["PPP1CB"]
NSD3 -->|"interacts with"| PPP1CB
H3K36["H3K36"]
NSD3 -->|"methylates"| H3K36
glycolysis(["glycolysis"])
NSD3 -->|"inhibits"| glycolysis
tumorigenesis["tumorigenesis"]
NSD3 -->|"contributes to"| tumorigenesis
MYC["MYC"]
NSD3 -->|"interacts with"| MYC
Carcinoma{"Carcinoma"}
NSD3 -->|"therapeutic target"| Carcinoma
Cancer{"Cancer"}
NSD3 -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
NSD3 -->|"therapeutic target"| Tumor
NSD3 -->|"inhibits"| Carcinoma
STAT3["STAT3"]
NSD3 -->|"inhibits"| STAT3
CANCER["CANCER"]
NSD3 -->|"therapeutic target"| CANCER
Epigenetic(["Epigenetic"])
NSD3 -->|"regulates"| Epigenetic
FGFR1["FGFR1"]
FGFR1 -->|"therapeutic target"| NSD3
SOX2["SOX2"]
SOX2 -->|"therapeutic target"| NSD3
CDK4["CDK4"]
CDK4 -->|"therapeutic target"| NSD3
RB1["RB1"]
RB1 -->|"therapeutic target"| NSD3
CDKN2A["CDKN2A"]
CDKN2A -->|"therapeutic target"| NSD3
EZH2["EZH2"]
EZH2 -->|"therapeutic target"| NSD3
PPP1CB -->|"inhibits"| NSD3
HK2["HK2"]
HK2 -->|"inhibits"| NSD3
style NSD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PPP1CB | interacts_with | protein | 0.90 |
| H3K36 | methylates | entity | 0.90 |
| glycolysis | inhibits | pathway | 0.80 |
| tumorigenesis | contributes_to | biological_process | 0.80 |
| MYC | interacts_with | protein | 0.80 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| STAT3 | inhibits | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| Glycolysis | inhibits | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||