| Gene Symbol | PTCH1 |
| Full Name | Patched 1 (Hedgehog Receptor) |
| Chromosome | 9q22.32 |
| Function | is a 12-pass transmembrane protein that functions as the negative regulator of the Hedgehog pathway by inhibiting Smoothened (SMO) in the absence of Hedgehog ligands[@gates2015]. |
| Primary Expression | several regions relevant to neurodegenerative disease[@khalil2019]: |
| Molecular Weight | 160 kDa |
| Amino Acids | 1448 aa |
| Exons | 24 |
| Pathways | signaling:
**Canonical Pathway**: |
| GeneCards | PTCH1 |
| Human Protein Atlas | PTCH1 |
| Approach | Mechanism |
| SMO agonists | Activate Hedgehog pathway |
| PTCH1 modulators | Modify pathway inhibition |
| GLI activators | Bypass upstream defects |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Interactions | SHH, NEURON, SYNAPSE, ATXN3, INFLAMMATION, APOPTOSIS |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |