gene 1,222 words KG: RAB7 2026-03-27
kind:genesection:genesstate:published
Contents

RAB7 Gene

🧬 Gene Info
Gene SymbolRAB7
Full NameRAB7, member RAS oncogene family
Chromosome3q21.3
FunctionRAB7 is a master regulator of late endosomal/lysosomal trafficking: - Late endosome maturation: Regulates transition from early to late endosomes - Lysosomal fusion: Controls SNARE-mediated fusion wit
Molecular Weight23 kDa
Amino Acids207 aa
Exons7
PathwaysPI3K
UniProt IDP51149
NCBI Gene ID7409
Ensembl IDENSG00000075711
OMIM602298
GeneCardsRAB7
Human Protein AtlasRAB7
Protein ClassSmall GTPase (Rab family)
Associated DiseasesALS, Ataxia, Neurodegeneration, disease
InteractionsRILP, MTOR, FYCO1, EGFR, RAB31, RAB7A
KG Connections214 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (9)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
BECN1 Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

RAB7 associated_with RILP
RAB7 activates RAB7A
RAB7 activates RILP
RAB7 associated_with RAB7A
RAB7 associated_with IGF2R
RAB7 regulates APP
RAB7 interacts_with MTOR
RAB7 regulates SPG21
RAB7 activates FYCO1
RAB7 regulates TFEB