protein 705 words KG: RAB7 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

RAB7 Protein

🔬 Protein Info
Gene SymbolRAB7
AliasesRAB7, member RAS oncogene family
FunctionRAB7 is a master regulator of late endosomal/lysosomal trafficking: - Late endosome maturation: Regulates transition from early to late endosomes - Lysosomal fusion: Controls SNARE-mediated fusion wit
Molecular Weight23 kDa
Amino Acids207 aa
Exons7
PathwaysPI3K
GeneCardsRAB7
Human Protein AtlasRAB7
ApproachStatus
RAB7 modulatorsResearch
[Autophagy](/entities/autophagy) enhancersResearch
Gene therapyPreclinical
Associated DiseasesALS, Ataxia, Neurodegeneration, disease
InteractionsRILP, MTOR, FYCO1, EGFR, RAB31, RAB7A
KG Connections214 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (10)

Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
BECN1 Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: expressed_in
ATG5 — Autophagy Related 5
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RAB7 activates RILP
RAB7 associated_with RAB7A
RAB7 associated_with IGF2R
RAB7 regulates APP
RAB7 interacts_with MTOR
RAB7 regulates SPG21
RAB7 activates FYCO1
RAB7 regulates TFEB
RAB7 interacts_with EGFR
RAB7 activates RAB31