gene 1,034 words KG: EED 2026-03-24
kind:genesection:genesstate:published
Contents

EED

🧬 Gene Info
Gene SymbolEED
Full NameEmbryonic Ectoderm Development
AliasesWAIT1, HEED, ESC
Chromosome11q14.2
Functionencodes a core scaffolding subunit of Polycomb Repressive Complex 2 (PRC2), the multisubunit complex responsible for trimethylation of histone H3 at lysine 27 (H3K27me3).
Gene TypeProtein-coding
PathwaysMapk, Microrna, Nf-Kb, Wnt
UniProt IDO75530
Ensembl IDENSG00000074266
OMIM605984
GeneCardsEED
Human Protein AtlasEED
HGNC3188
Entrez Gene8726
R236TMissense
Associated Diseasesneurodegeneration
InteractionsLRP1, TAU, TREM2, MS4A6A, TAU PATHOLOGY, ALZHEIMER
KG Connections150 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (3)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
CTSB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

EED associated_with GRN
EED associated_with INPP5D
EED associated_with LILRB2
EED associated_with PICALM
EED associated_with PLCG2
EED associated_with PSEN1
EED associated_with PTK2B
EED associated_with SORL1
EED associated_with SPI1
EED associated_with TMEM106B