gene 1,229 words KG: LILRB2 2026-03-24
kind:genesection:genesstate:published
Contents

LILRB2 — Leukocyte Immunoglobulin-Like Receptor B2

🧬 Gene Info
Gene SymbolLILRB2
Full NameLeukocyte Immunoglobulin-Like Receptor B2
Chromosome19q13.42
Protein TypeReceptor
Functionencodes an inhibitory immunoreceptor on chromosome 19q13.
Primary ExpressionMicroglia, Macrophages, Monocytes, Dendritic cells, Osteoclasts
Amino Acids598 aa
Exons16
PathwaysAmyloid, Complement, Phagocytosis, Stem Cell
UniProt IDQ8N423
NCBI Gene ID10288
Ensembl IDENSG00000131042
OMIM604815
GeneCardsLILRB2
Human Protein AtlasLILRB2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
InteractionsTREM2, LRP1, TAU, CYTOKINES, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections149 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (9)

Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
BIN1 — Bridging Integrator 1
gene · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LILRB2 inhibits TREM2
LILRB2 associated_with PICALM
LILRB2 associated_with PLCG2
LILRB2 associated_with PSEN1
LILRB2 associated_with PTK2B
LILRB2 associated_with SORL1
LILRB2 associated_with SPI1
LILRB2 associated_with TMEM106B
LILRB2 associated_with TREM2
LILRB2 activates LRP1