gene 749 words KG: STAR 2026-03-29
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

STAR — Steroidogenic Acute Regulatory Protein

🧬 Gene Info
Gene SymbolSTAR
Full NameSteroidogenic Acute Regulatory Protein
AliasesStAR, START1, STARD1
Chromosome8p11.23
FunctionCholesterol accumulates at mitochondria-ER contact sites
Primary ExpressionBrain (neurons, glia), adrenal gland, gonads
Amino Acids285 aa
PathwaysAngiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt IDP49675
NCBI Gene ID6779
Ensembl IDENSG00000147548
GeneCardsSTAR
Human Protein AtlasSTAR
Associated DiseasesAging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
InteractionsGAIN, CAT, GPX1, CHR2, Mek, AKT
KG Connections179 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
CD8 Gene
gene · KG edge: associated_with
CD4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

STAR expressed_in CD8
STAR associated_with PP2A
STAR inhibits GAIN
STAR activates CAT
STAR activates GPX1
STAR activates CHR2
STAR expressed_in CD4
STAR associated_with APP
STAR associated_with NRF2
STAR expressed_in TNF