| Gene Symbol | SYK |
| Chromosome | 9q22 |
| Protein Family | Src family tyrosine kinases |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | brain microglia (Iba1+ cells)
- Increased expression in disease states
- Localizes to amyloid plaques in AD |
| Molecular Weight | ~72 kDa |
| Amino Acids | 629 aa |
| Exons | 18 |
| Pathways | PI3K, MAPK |
| UniProt ID | P43405 |
| NCBI Gene ID | 6715 |
| GeneCards | SYK |
| Human Protein Atlas | SYK |
| Gene Name | Spleen Tyrosine Kinase |
| Associated Diseases | ALS, Alzheimer, CYTOKINES, PYROPTOSIS |
| Known Drugs/Compounds | Entospletinib, Pustulan, metformin, R406 |
| Interactions | TREM2, DAP12, MTOR, AKT, NLRP3, JNK |
| KG Connections | 367 knowledge graph edges |
| Databases | GeneCardsHPASTRING |