gene 2,227 words KG: SYNAPTOPHYSIN
Contents

SYNAPTOPHYSIN Gene

🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids313 aa
Exons4
PathwaysOxidative Stress
UniProt ID[P08247](https://www.uniprot.org/uniprot/P08247)
NCBI Gene ID6855
Ensembl IDENSG00000157193
OMIM313475
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesAlzheimer, Motor function, Motor function recovery, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsSYNCRIP, SNAP25, MTOR, P38, GFAP, TNF
KG Connections444 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Purinergic Signaling Polarization Control
Score: 0.55

Related Analyses (23)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (12)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (5)

Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
ATG9A Gene
gene · KG edge: co-localizes
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
blarcamesine-axon
clinical_trial · KG edge: inhibits

Knowledge Graph (12 edges)

SYNAPTOPHYSIN biomarker_for BACE1
SYNAPTOPHYSIN biomarker_for NFL
SYNAPTOPHYSIN activates IL6
SYNAPTOPHYSIN activates BDNF
SYNAPTOPHYSIN activates GFAP
SYNAPTOPHYSIN activates RAB5
SYNAPTOPHYSIN expressed_in ATG9A
SYNAPTOPHYSIN protects_against CASP1
SYNAPTOPHYSIN protects_against VEGF
SYNAPTOPHYSIN associated_with GFAP