gene 785 words KG: SYP 2026-03-21
kind:genesection:genesstate:published
Contents

SYP Gene

🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight38 kDa
Amino Acids313 aa
Exons4
PathwaysOxidative Stress
UniProt ID[P08247](https://www.uniprot.org/uniprot/P08247)
Ensembl IDENSG00000157193
OMIM313475
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesAlzheimer, Motor function, Motor function recovery, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsSYNCRIP, SNAP25, MTOR, P38, GFAP, TNF
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

SYP interacts_with SYNCRIP
SYP regulates CHRNA7
SYP regulates SYT1
SYP regulates STAT3
SYP regulates HMOX1
SYP regulates TRPV1
SYP regulates P2RY2
SYP regulates FOXP3
SYP regulates TPH2
SYP regulates CCL3