gene 883 words KG: CXCL2 2026-03-26
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:als
Contents

CXCL2 — C-X-C Motif Chemokine Ligand 2

🧬 Gene Info
Gene SymbolCXCL2
Full NameC-X-C Motif Chemokine Ligand 2
AliasesMIP-2
Chromosome4q21.1
Functionis a small chemokine protein that plays critical roles in inflammation, immune cell recruitment, and neuroinflammation.
Molecular Weight7.8 kDa
Amino Acids99 aa
PathwaysPI3K, MAPK, NF-κB pathway
UniProt ID[P19875](https://www.uniprot.org/uniprot/P19875)
Ensembl IDENSG00000024836
GeneCardsCXCL2
Human Protein AtlasCXCL2
Associated DiseasesAlzheimer, Inflammation
InteractionsIL6, IL12B, CXCL1, CLDN5, OCLN, IL23A
KG Connections269 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (2)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
CXCL1
gene · KG edge: activates

Knowledge Graph (12 edges)

CXCL2 activates IL12B
CXCL2 activates IL23A
CXCL2 activates IL6
CXCL2 activates OCLN
CXCL2 inhibits IL6
CXCL2 therapeutic_target ATF4
CXCL2 therapeutic_target PPP1R15A
CXCL2 inhibits IL12B
CXCL2 therapeutic_target XBP1
CXCL2 inhibits CXCL1