gene 682 words KG: RELB 2026-03-22
kind:genesection:genesstate:published
Contents

RELB Gene

🧬 Gene Info
Gene SymbolNF
Full NameκB RelB Protein
AliasesRELB
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELB is a NF-κB family member that primarily partners with p52 to form the non-canonical NF-κB pathway.
Primary Expressionglial cells and may have neuroprotective or inflammatory roles in the brain
Molecular Weight66 kDa
PathwaysNF-κB, NF-κB Pathway, NF-κB pathway, NF-κB signaling, NFKB
UniProt ID[Q02880](https://www.uniprot.org/uniprot/Q02880)
GeneCardsNF
Human Protein AtlasNF
NF-κB inhibitorsBroad-spectrum anti-inflammatory
RELB-specific inhibitorsTargeted therapy
Gene therapyModulate RELB expression
Associated DiseasesAls, Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor
InteractionsIGF1, RPS6KB1, TNF, NF-ΚB, CANCER, INFLAMMATION
KG Connections95 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: expressed_in
RELA (NF-κB p65)
gene · KG edge: expressed_in
REL Gene
gene · KG edge: expressed_in
PANX1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

RELB regulates P2RY1
RELB regulates CASP3
RELB regulates SOCS3
RELB regulates TRPA1
RELB regulates CXCL2
RELB regulates SNAP25
RELB regulates P2RX7
RELB regulates SYT2
RELB regulates TNF
RELB regulates SOD2