gene 561 words KG: UGCG 2026-03-22
kind:genesection:genesstate:published
Contents

UGCG Gene

🧬 Gene Info
Gene SymbolUGCG
AliasesUDP-Glucose Ceramide Glucosyltransferase
FunctionThe UGCG gene encodes UDP-glucose ceramide glucosyltransferase (UGCG), also known as glucosylceramide synthase.
Primary Expressionglial cells including astrocytes and oligodendrocytes
Subcellular Localizationthe Golgi apparatus where it transfers glucose from UDP-glucose to ceramide. Dysregulation of glycosphingolipid metaboli
Molecular Weight46 kDa
PathwaysApoptosis, Nf-Κb, Oxidative Stress, Wnt, apoptosis pathway
Ensembl IDENSG00000165269
GeneCardsUGCG
Human Protein AtlasUGCG
Associated DiseasesAls
InteractionsSTING, RAB5, TSG101, CD63, CD9, RAB35
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Sphingolipid Metabolism Reprogramming
Score: 0.44

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: activates
Sphingolipid Metabolism in Neurodegeneration
mechanism · KG edge: associated_with
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

UGCG activates STING
UGCG activates RAB5
UGCG activates Heart Failure
UGCG interacts_with Als
UGCG associated_with Sphingolipid
UGCG activates Oxidative Stress
UGCG activates Cancer
UGCG activates Nf-Κb
UGCG activates Wnt
UGCG activates Apoptosis