gene 1,504 words KG: RAB5
Contents

RAB5A Gene

🧬 Gene Info
Gene SymbolRAB5A
Full NameRAB5A, member RAS oncogene family
Chromosome3p24.3
Functionencodes a critical small GTPase that serves as the master regulator of early endosome function.
Molecular Weight23.5 kDa
Amino Acids218 aa
PathwaysApoptosis, Autophagy, Endocytosis, Mitophagy, VESICLE_TRAFFICKING
UniProt IDP20339
NCBI Gene ID5868
Ensembl IDENSG00000112984
OMIM171585
GeneCardsRAB5A
Human Protein AtlasRAB5A
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Dementia
InteractionsAlbumin, ALS2, AND, ARHGEF7, ATG, ATG9A
KG Connections384 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (38)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
APOE-Dependent Autophagy Restoration
Score: 0.89
SASP-Mediated Complement Cascade Amplification
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
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Related Analyses (12)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (5)

Amyotrophic Lateral Sclerosis
redirect · KG edge: causes
ALS2 (Alsin)
gene · KG edge: causes
Alzheimer Indonesia
institution · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

RAB5 regulates VESICLE_TRAFFICKING
RAB5 inhibits neurodegeneration
ELAVL2 therapeutic_target RAB5
C1Q inhibits RAB5
MTOR therapeutic_target RAB5
CLPP therapeutic_target RAB5
RAB11 inhibits RAB5
STX17 therapeutic_target RAB5
RAB5 therapeutic_target SNAP29
RAB5 therapeutic_target IGF2BP1

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