gene 960 words KG: VPS37B 2026-03-28
kind:genesection:genesstate:published
Contents

VPS37B Gene

🧬 Gene Info
Gene SymbolVPS37B
Full NameVacuolar Protein Sorting 37 Homolog B
Chromosome14q23.3
Functionis a core component of the ESCRT-I (Endosomal Sorting Complex Required for Transport-I) complex, critical for endosomal trafficking and multivesicular body (MVB) formation[@structure2009].
Subcellular LocalizationEndosomal membrane
Molecular Weight21 kDa
Amino Acids184
Gene TypeProtein coding
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
UniProt IDQ9H8Y8
NCBI Gene ID203197
Ensembl IDENSG00000139517
OMIM
GeneCardsVPS37B
Human Protein AtlasVPS37B
Associated Diseasesneurodegeneration
KG Connections66 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Extracellular Vesicle Biogenesis Modulation
Score: 0.34
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Autophagosome Maturation Checkpoint Control
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

NDRG2 — N-myc Downstream Regulated Gene 2
gene · KG edge: regulates
MYH2 Gene
gene · KG edge: regulates
MERTK - MER Tyrosine Kinase
gene · KG edge: regulates
LITAF — Lipopolysaccharide-Induced Tumor Necrosis Facto
gene · KG edge: regulates
JUN Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

VPS37B associated_with CHMP4B
VPS37B regulates NFKBIA
VPS37B regulates CALM2
VPS37B regulates NPY1R
VPS37B regulates LITAF
VPS37B regulates SESN1
VPS37B regulates PDK4
VPS37B regulates MYH2
VPS37B regulates CDKN1A
VPS37B regulates JUN