concept

HAVCR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HAVCR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

1Hypotheses

1Analyses

14Outgoing

7Incoming

0Experiments

1Debates

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💡 Concept Info

Name	HAVCR2
Key Genes/Proteins	CSF2, CSF2RA, EPO, EPOR, FGF2, FGF8
Related Diseases	Alzheimer'S Disease
Related Pathways	co-inhibitory gene module, Co-inhibitory Gene Module, microglial activation

Pathway Diagram

graph TD
    HAVCR2[HAVCR2]
    HAVCR2 -->|component_of| Co_inhibitory_Gene_Module[Co-inhibitory Gene Module]
    HAVCR2 -->|expressed in| co_inhibitory_gene_module[co-inhibitory gene module]
    HAVCR2 -->|encodes| TIM_3[TIM-3]
    HAVCR2 -->|expressed in| microglia[microglia]
    HAVCR2 -->|regulates| HSPA1A[HSPA1A]
    HAVCR2 -->|regulates| NAMPT[NAMPT]
    HAVCR2 -->|regulates| S100A8[S100A8]
    HAVCR2 -->|regulates| TLR4[TLR4]
    HAVCR2 -->|regulates| LGALS9[LGALS9]
    HAVCR2 -->|expressed in| macrophages[macrophages]
    CSF2[CSF2] -->|regulates| HAVCR2
    CSF2RA[CSF2RA] -->|regulates| HAVCR2
    FGF2[FGF2] -->|regulates| HAVCR2
    FGF8[FGF8] -->|regulates| HAVCR2
    EPO[EPO] -->|regulates| HAVCR2
    EPOR[EPOR] -->|regulates| HAVCR2
    benchmark_ot_ad_answer_key_HAV[benchmark_ot_ad_answer_key:HAVCR2] -->|data_in| HAVCR2

Outgoing (14)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HAVCR2	data_in	dataset_row	0.00
Alzheimer'S Disease	associated_with	disease	0.95
Co-inhibitory Gene Module	component_of	pathway	0.95
microglial activation	regulates	mechanism	0.90
co-inhibitory gene module	expressed_in	pathway	0.85
TIM-3	encodes	protein	0.80
microglia	expressed_in	cell_type	0.70
LGALS9	regulates	gene	0.60
macrophages	expressed_in	cell_type	0.60
HSPA1A	regulates	gene	0.60
NAMPT	regulates	gene	0.60
S100A8	regulates	gene	0.60
TLR4	regulates	gene	0.60
TUMOR CELLS	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HAVCR2	data_in	dataset_row	0.00
CSF2	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
FGF2	regulates	gene	0.60
FGF8	regulates	gene	0.60
EPO	regulates	gene	0.60
EPOR	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TIM-3 Checkpoint Modulation in Microglia	0.000	-	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 12 hypotheses Top: 0.726

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning HAVCR2 in their description or question text

No additional research found