concept

LGALS9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LGALS9
Key Genes/Proteins	CSF2RA
Related Diseases	Ischemic Stroke, ALS, Neuroinflammation, Ischemia, Stroke

Pathway Diagram

graph TD
    LGALS9["LGALS9"]
    LGALS9 -->|"interacts"| CD44["CD44"]
    LGALS9 -.biomarker for.-> Ischemic_Stroke["Ischemic Stroke"]
    LGALS9 -->|"regulates"| ALS["ALS"]
    LGALS9 -->|"regulates"| Stroke["Stroke"]
    LGALS9 -->|"regulates"| Als["Als"]
    LGALS9 -->|"encodes"| Ischemia["Ischemia"]
    LGALS9 -->|"encodes"| Neuroinflammation["Neuroinflammation"]
    Microglia["Microglia"] -->|"expressed in"| LGALS9
    Macrophages["Macrophages"] -->|"expressed in"| LGALS9
    Extracellular_Vesicles["Extracellular Vesicles"] -->|"mediates"| LGALS9
    ISG15["ISG15"] -->|"regulates"| LGALS9
    ERK["ERK"] -->|"regulates"| LGALS9
    CD44 -->|"interacts"| LGALS9
    AND["AND"] -->|"interacts"| LGALS9
    STROKE["STROKE"] -->|"regulates"| LGALS9

Outgoing (58)

Target	Relation	Type	Str
Ischemic Stroke	biomarker_for	disease	0.85
ALS	regulates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Ischemia	encodes	disease	0.65
Neuroinflammation	encodes	disease	0.65
Als	activates	disease	0.65
Aging	regulates	disease	0.65
Cancer	activates	disease	0.65
CSF2RA	regulates	gene	0.60
EPOR	regulates	gene	0.60
STAT1	regulates	gene	0.60
MAPK	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
P38	regulates	gene	0.60
CXCL10	regulates	gene	0.60
BCL-2	regulates	gene	0.60
FGF8	regulates	gene	0.60
AKT	regulates	gene	0.60
S100A8	regulates	gene	0.60
CSF2	regulates	gene	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
TLR4	regulates	gene	0.60
NAMPT	regulates	gene	0.60
EPO	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
MICROGLIA	interacts_with	gene	0.60
ISG15	regulates	gene	0.60
RNA	associated_with	gene	0.60
Macrophage	interacts_with	cell_type	0.60
Microglia	interacts_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
AND	interacts_with	gene	0.60
Neutrophil	regulates	cell_type	0.60
Interferon	regulates	protein	0.60
Cytokine	regulates	protein	0.60
RNA	encodes	gene	0.60
Neuron	encodes	cell_type	0.60
ERK	regulates	gene	0.60
Rb	regulates	protein	0.60
Fgf	regulates	protein	0.60
Ubiquitin	regulates	protein	0.60
Pi3K/Akt	activates	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
Microglia	expressed_in	cell_type	0.90
Macrophages	expressed_in	cell_type	0.90
Extracellular Vesicles	mediates	compound	0.80
ISG15	regulates	gene	0.60
ERK	regulates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
CD44	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
AND	interacts_with	gene	0.60
STROKE	regulates	gene	0.60
TLR4	regulates	gene	0.60
P38	regulates	gene	0.60
CXCL10	regulates	gene	0.60
FGF2	regulates	gene	0.60
S100A8	regulates	gene	0.60
FGF8	regulates	gene	0.60
STAT1	regulates	gene	0.60
EPO	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
EPOR	regulates	gene	0.60
AKT	regulates	gene	0.60
MAPK	regulates	gene	0.60
CSF2	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
BCL-2	regulates	gene	0.60
AND	regulates	gene	0.60
GENES	regulates	gene	0.60
NAMPT	regulates	gene	0.60
PI3K	regulates	gene	0.60
MICROGLIA	interacts_with	gene	0.60
HERC5	interacts_with	gene	0.60
HAVCR2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found