Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSF2RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CSF2RA encodes the alpha chain of the GM-CSF receptor, mediating cytokine signaling in microglia and immune cells
| Gene Symbol | CSF2RA |
| Full Name | Colony Stimulating Factor 2 Receptor Alpha Chain |
| Protein Type | Receptor |
| Function | is a critical cell surface receptor that mediates the pleiotropic effects of GM-CSF on myeloid lineage cells. |
| Molecular Weight | 85 kDa |
| Amino Acids | 90 aa |
| Exons | 14 |
| Pathways | Akt, Mapk, Pi3K, Pi3K/Akt |
| GeneCards | CSF2RA |
| Human Protein Atlas | CSF2RA |
| Associated Diseases | neurodegeneration |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CSF2RA["<b>CSF2RA</b>"]
Als{"Als"}
CSF2RA -->|"regulates"| Als
ALS{"ALS"}
CSF2RA -->|"regulates"| ALS
S100A8["S100A8"]
CSF2RA -->|"regulates"| S100A8
Pi3K(["Pi3K"])
CSF2RA -->|"regulates"| Pi3K
Akt(["Akt"])
CSF2RA -->|"regulates"| Akt
Mapk(["Mapk"])
CSF2RA -->|"regulates"| Mapk
ERK["ERK"]
CSF2RA -->|"regulates"| ERK
NAMPT["NAMPT"]
CSF2RA -->|"regulates"| NAMPT
CSF2["CSF2"]
CSF2RA -->|"regulates"| CSF2
HSPA1A["HSPA1A"]
CSF2RA -->|"regulates"| HSPA1A
STAT1["STAT1"]
CSF2RA -->|"regulates"| STAT1
BCL_2["BCL-2"]
CSF2RA -->|"regulates"| BCL_2
CSF2 -->|"regulates"| CSF2RA
NAMPT -->|"regulates"| CSF2RA
FGF2["FGF2"]
FGF2 -->|"regulates"| CSF2RA
CXCL10["CXCL10"]
CXCL10 -->|"regulates"| CSF2RA
HSPA1A -->|"regulates"| CSF2RA
FGF8["FGF8"]
FGF8 -->|"regulates"| CSF2RA
TLR4["TLR4"]
TLR4 -->|"regulates"| CSF2RA
ISG15["ISG15"]
ISG15 -->|"regulates"| CSF2RA
STAT1 -->|"regulates"| CSF2RA
P38["P38"]
P38 -->|"regulates"| CSF2RA
ERK -->|"regulates"| CSF2RA
PI3K["PI3K"]
PI3K -->|"regulates"| CSF2RA
style CSF2RA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| S100A8 | regulates | gene | 0.60 |
| NAMPT | regulates | gene | 0.60 |
| CSF2 | regulates | gene | 0.60 |
| HSPA1A | regulates | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| P38 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| FGF8 | regulates | gene | 0.60 |
| ISG15 | regulates | gene | 0.60 |
| FGF2 | regulates | gene | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| HAVCR2 | regulates | gene | 0.60 |
| Pi3K | regulates | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| ERK | regulates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| EPOR | regulates | gene | 0.60 |
| EPO | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| Pi3K/Akt | regulates | pathway | 0.60 |
| MAPK | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| LGALS9 | regulates | gene | 0.60 |
| Neutrophil | regulates | cell_type | 0.60 |
| Interferon | regulates | protein | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Fgf | regulates | protein | 0.60 |
| Ubiquitin | regulates | protein | 0.60 |
| CYTOKINE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CSF2 | regulates | gene | 0.60 |
| NAMPT | regulates | gene | 0.60 |
| FGF2 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| HSPA1A | regulates | gene | 0.60 |
| FGF8 | regulates | gene | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| ISG15 | regulates | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| P38 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| S100A8 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| EPOR | regulates | gene | 0.60 |
| EPO | regulates | gene | 0.60 |
| LGALS9 | regulates | gene | 0.60 |
| MAPK | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||