gene

CSF2RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF2RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections
0Hypotheses
0Analyses
35Outgoing
20Incoming

Summary

CSF2RA encodes the alpha chain of the GM-CSF receptor, mediating cytokine signaling in microglia and immune cells

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🧬 Gene Info
Gene SymbolCSF2RA
Full NameColony Stimulating Factor 2 Receptor Alpha Chain
Protein TypeReceptor
Functionis a critical cell surface receptor that mediates the pleiotropic effects of GM-CSF on myeloid lineage cells.
Molecular Weight85 kDa
Amino Acids90 aa
Exons14
PathwaysAkt, Mapk, Pi3K, Pi3K/Akt
GeneCardsCSF2RA
Human Protein AtlasCSF2RA
Associated Diseasesneurodegeneration
KG Connections55 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

CSF2RA — Colony Stimulating Factor 2 Receptor Alpha Chain

gene · 1774 words

FGF8 Gene

gene · 2232 words

GM-CSF Receptor Alpha Chain

protein · 1580 words

GM-CSF Receptor Common Beta Chain

protein · 1526 words

CSF2 — Colony Stimulating Factor 2 (GM-CSF)

gene · 1300 words

csf2rb

gene · 1300 words

Pathway Diagram

graph TD
    CSF2RA["<b>CSF2RA</b>"]
    Als{"Als"}
    CSF2RA -->|"regulates"| Als
    ALS{"ALS"}
    CSF2RA -->|"regulates"| ALS
    S100A8["S100A8"]
    CSF2RA -->|"regulates"| S100A8
    Pi3K(["Pi3K"])
    CSF2RA -->|"regulates"| Pi3K
    Akt(["Akt"])
    CSF2RA -->|"regulates"| Akt
    Mapk(["Mapk"])
    CSF2RA -->|"regulates"| Mapk
    ERK["ERK"]
    CSF2RA -->|"regulates"| ERK
    NAMPT["NAMPT"]
    CSF2RA -->|"regulates"| NAMPT
    CSF2["CSF2"]
    CSF2RA -->|"regulates"| CSF2
    HSPA1A["HSPA1A"]
    CSF2RA -->|"regulates"| HSPA1A
    STAT1["STAT1"]
    CSF2RA -->|"regulates"| STAT1
    BCL_2["BCL-2"]
    CSF2RA -->|"regulates"| BCL_2
    CSF2 -->|"regulates"| CSF2RA
    NAMPT -->|"regulates"| CSF2RA
    FGF2["FGF2"]
    FGF2 -->|"regulates"| CSF2RA
    CXCL10["CXCL10"]
    CXCL10 -->|"regulates"| CSF2RA
    HSPA1A -->|"regulates"| CSF2RA
    FGF8["FGF8"]
    FGF8 -->|"regulates"| CSF2RA
    TLR4["TLR4"]
    TLR4 -->|"regulates"| CSF2RA
    ISG15["ISG15"]
    ISG15 -->|"regulates"| CSF2RA
    STAT1 -->|"regulates"| CSF2RA
    P38["P38"]
    P38 -->|"regulates"| CSF2RA
    ERK -->|"regulates"| CSF2RA
    PI3K["PI3K"]
    PI3K -->|"regulates"| CSF2RA
    style CSF2RA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

TargetRelationTypeStr
Alsregulatesdisease0.65
ALSregulatesdisease0.65
S100A8regulatesgene0.60
NAMPTregulatesgene0.60
CSF2regulatesgene0.60

Incoming (20)

SourceRelationTypeStr
CSF2regulatesgene0.60
NAMPTregulatesgene0.60
FGF2regulatesgene0.60
CXCL10regulatesgene0.60
HSPA1Aregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found