gene

FGF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections
0Hypotheses
0Analyses
29Outgoing
22Incoming

Summary

FGF8 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with ALS, Als. Connected to 42 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolFGF8
Full NameFibroblast Growth Factor 8
Chromosome10q24.33
Functionencodes a critical signaling molecule belonging to the FGF family of heparin-binding growth factors.
Primary ExpressionBrain (frontal cortex, hippocampus), substantia nigra, hypothalamus, SVZ
Molecular Weight24 kDa
Amino Acids215 aa
PathwaysAkt, Mapk, Pi3K, Pi3K/Akt
UniProt ID[P55075](https://www.uniprot.org/uniprot/P55075)
Ensembl IDENSG00000107882
GeneCardsFGF8
Human Protein AtlasFGF8
FGF8aThe most common isoform, widely expressed during development
FGF8bMore potent in certain contexts, particularly in neural specification
FGF8c/d/e/fLess characterized isoforms with tissue-specific expression
Associated Diseasesneurodegeneration
KG Connections51 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

FGF8 Gene

gene · 2232 words

FGF10 — Fibroblast Growth Factor 10

gene · 3796 words

mitochondrial-dynamics-dysfunction-parkinsons

general · 3785 words

FGF Signaling Pathway in Neurodegeneration

mechanism · 3211 words

lmx1b

gene · 3191 words

PITX3 Protein

protein · 2967 words

Pathway Diagram

graph TD
    FGF8["<b>FGF8</b>"]
    Als{"Als"}
    FGF8 -->|"regulates"| Als
    ALS{"ALS"}
    FGF8 -->|"regulates"| ALS
    TLR4["TLR4"]
    FGF8 -->|"regulates"| TLR4
    ISG15["ISG15"]
    FGF8 -->|"regulates"| ISG15
    STAT1["STAT1"]
    FGF8 -->|"regulates"| STAT1
    CSF2RA["CSF2RA"]
    FGF8 -->|"regulates"| CSF2RA
    S100A8["S100A8"]
    FGF8 -->|"regulates"| S100A8
    Pi3K(["Pi3K"])
    FGF8 -->|"regulates"| Pi3K
    Akt(["Akt"])
    FGF8 -->|"regulates"| Akt
    Mapk(["Mapk"])
    FGF8 -->|"regulates"| Mapk
    CSF2["CSF2"]
    FGF8 -->|"regulates"| CSF2
    AKT["AKT"]
    FGF8 -->|"regulates"| AKT
    CSF2 -->|"regulates"| FGF8
    NAMPT["NAMPT"]
    NAMPT -->|"regulates"| FGF8
    FGF2["FGF2"]
    FGF2 -->|"regulates"| FGF8
    CXCL10["CXCL10"]
    CXCL10 -->|"regulates"| FGF8
    HSPA1A["HSPA1A"]
    HSPA1A -->|"regulates"| FGF8
    P38["P38"]
    P38 -->|"regulates"| FGF8
    ERK["ERK"]
    ERK -->|"regulates"| FGF8
    PI3K["PI3K"]
    PI3K -->|"regulates"| FGF8
    STAT1 -->|"regulates"| FGF8
    S100A8 -->|"regulates"| FGF8
    GENES["GENES"]
    GENES -->|"regulates"| FGF8
    BCL_2["BCL-2"]
    BCL_2 -->|"regulates"| FGF8
    style FGF8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
Alsregulatesdisease0.65
ALSregulatesdisease0.65
TLR4regulatesgene0.60
ISG15regulatesgene0.60
STAT1regulatesgene0.60

Incoming (22)

SourceRelationTypeStr
CSF2regulatesgene0.60
NAMPTregulatesgene0.60
FGF2regulatesgene0.60
CXCL10regulatesgene0.60
HSPA1Aregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found