Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF8 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with ALS, Als. Connected to 42 entities in the SciDEX knowledge graph.
| Gene Symbol | FGF8 |
| Full Name | Fibroblast Growth Factor 8 |
| Chromosome | 10q24.33 |
| Function | encodes a critical signaling molecule belonging to the FGF family of heparin-binding growth factors. |
| Primary Expression | Brain (frontal cortex, hippocampus), substantia nigra, hypothalamus, SVZ |
| Molecular Weight | 24 kDa |
| Amino Acids | 215 aa |
| Pathways | Akt, Mapk, Pi3K, Pi3K/Akt |
| UniProt ID | [P55075](https://www.uniprot.org/uniprot/P55075) |
| Ensembl ID | ENSG00000107882 |
| GeneCards | FGF8 |
| Human Protein Atlas | FGF8 |
| FGF8a | The most common isoform, widely expressed during development |
| FGF8b | More potent in certain contexts, particularly in neural specification |
| FGF8c/d/e/f | Less characterized isoforms with tissue-specific expression |
| Associated Diseases | neurodegeneration |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FGF8["<b>FGF8</b>"]
Als{"Als"}
FGF8 -->|"regulates"| Als
ALS{"ALS"}
FGF8 -->|"regulates"| ALS
TLR4["TLR4"]
FGF8 -->|"regulates"| TLR4
ISG15["ISG15"]
FGF8 -->|"regulates"| ISG15
STAT1["STAT1"]
FGF8 -->|"regulates"| STAT1
CSF2RA["CSF2RA"]
FGF8 -->|"regulates"| CSF2RA
S100A8["S100A8"]
FGF8 -->|"regulates"| S100A8
Pi3K(["Pi3K"])
FGF8 -->|"regulates"| Pi3K
Akt(["Akt"])
FGF8 -->|"regulates"| Akt
Mapk(["Mapk"])
FGF8 -->|"regulates"| Mapk
CSF2["CSF2"]
FGF8 -->|"regulates"| CSF2
AKT["AKT"]
FGF8 -->|"regulates"| AKT
CSF2 -->|"regulates"| FGF8
NAMPT["NAMPT"]
NAMPT -->|"regulates"| FGF8
FGF2["FGF2"]
FGF2 -->|"regulates"| FGF8
CXCL10["CXCL10"]
CXCL10 -->|"regulates"| FGF8
HSPA1A["HSPA1A"]
HSPA1A -->|"regulates"| FGF8
P38["P38"]
P38 -->|"regulates"| FGF8
ERK["ERK"]
ERK -->|"regulates"| FGF8
PI3K["PI3K"]
PI3K -->|"regulates"| FGF8
STAT1 -->|"regulates"| FGF8
S100A8 -->|"regulates"| FGF8
GENES["GENES"]
GENES -->|"regulates"| FGF8
BCL_2["BCL-2"]
BCL_2 -->|"regulates"| FGF8
style FGF8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| TLR4 | regulates | gene | 0.60 |
| ISG15 | regulates | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| CSF2RA | regulates | gene | 0.60 |
| S100A8 | regulates | gene | 0.60 |
| CSF2 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| P38 | regulates | gene | 0.60 |
| NAMPT | regulates | gene | 0.60 |
| HSPA1A | regulates | gene | 0.60 |
| FGF2 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| HAVCR2 | regulates | gene | 0.60 |
| Pi3K | regulates | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| ERK | regulates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| Pi3K/Akt | regulates | pathway | 0.60 |
| EPO | regulates | gene | 0.60 |
| EPOR | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MAPK | regulates | gene | 0.60 |
| LGALS9 | regulates | gene | 0.60 |
| CYTOKINE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CSF2 | regulates | gene | 0.60 |
| NAMPT | regulates | gene | 0.60 |
| FGF2 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| HSPA1A | regulates | gene | 0.60 |
| P38 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| S100A8 | regulates | gene | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| ISG15 | regulates | gene | 0.60 |
| CSF2RA | regulates | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| FGF2 | associated_with | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| EPOR | regulates | gene | 0.60 |
| EPO | regulates | gene | 0.60 |
| LGALS9 | regulates | gene | 0.60 |
| MAPK | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||