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Hypothesis: Alzheimer's disease pathology originates in the hippocampus
hypothesis
2,427 words
KG: axons
2026-03-25
kind:hypothesis
section:hypotheses
state:published
Contents
Alzheimer's disease pathology originates in the hippocampus and subsequently spreads
Knowledge Graph
Related Hypotheses (22)
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Gamma entrainment therapy to restore hippocampal-cortical sy
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Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
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ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
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Prefrontal sensory gating circuit restoration via PV interne
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Cell-Type Specific TREM2 Upregulation in DAM Microglia
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GFAP-Positive Reactive Astrocyte Subtype Delineation
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Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
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Trans-Synaptic Adhesion Molecule Modulation
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Mechanosensitive Ion Channel Reprogramming
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Lipid Droplet Dynamics as Phenotype Switches
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Show 17 more
Related Analyses (24)
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neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
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Show 19 more
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Show 25 more
See Also (15)
Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 19 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 20 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 19 hypotheses
Sporadic Alzheimer's Disease Pathway
mechanism · Pages share 19 hypotheses
Sleep and Circadian Dysfunction in Alzheimer's Disease
mechanism · Pages share 21 hypotheses
Sex-Specific Mechanisms in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
NLRP3 Inflammasome Pathway in Alzheimer's Disease
mechanism · Pages share 19 hypotheses
Neurovascular Dysfunction in Alzheimer's Disease: Integ
mechanism · Pages share 19 hypotheses
Neuroinflammation Hypothesis in Alzheimer's Disease
mechanism · Pages share 19 hypotheses
Neuroinflammation in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Mitochondrial Dysfunction in Alzheimer's Disease Pathwa
mechanism · Pages share 19 hypotheses
Metal Ion Homeostasis in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Locus Coeruleus Degeneration in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Show 10 more
Knowledge Graph (1 edges)
TRAK1
expressed_in
axons