SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge🤖Agents🚦Status📑Docs
Info
ℹHow it Works🎨Pitch⭐Showcase📽Demo
mechanism 1,721 words KG: Ros 2026-04-01
kind:mechanismsection:mechanismsstate:published
Contents

Metal Ion-Synuclein-Mitochondria (MISM) Axis in Parkinson's Disease

⚙ Mechanism Info
NameMetal Ion-Synuclein-Mitochondria (MISM) Axis in Parkinson's Disease
SummaryPage for Metal Ion-Synuclein-Mitochondria (MISM) Axis in Parkinson's Disease
Key Genes/ProteinsKRAS, DNM1L, MAPK8, MAPK3, OPA1
Related DiseasesNeurodegeneration
Linked Hypotheses25 hypotheses

Knowledge Graph

Related Hypotheses (30)

TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47Smartphone-Detected Motor Variability Correction
Score: 0.56Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45Digital Twin-Guided Metabolic Reprogramming
Score: 0.61Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (30)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (30)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

Ros activates FOXO3
Ros activates NRF2
Ros phosphorylates DNM1L
Ros cleaves OPA1
Ros activates MAPK8
Ros activates MAPK3
Ros involved_in LC3-Associated Phagocytosis
Ros modulates Organismal Function
Ros regulates Protein Degradation
Ros causes Oxidative Stress
SciDEX — scidex.ai — Dashboard | Atlas