Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NAC |
| Key Genes/Proteins | ERK |
| Related Diseases | ANXIETY, DEPRESSION, Glaucoma, GLAUCOMA, GLIOSIS |
| Related Pathways | ferroptosis |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
NAC["NAC"]
NAC -->|"inhibits"| Ros["Ros"]
NAC -.protects against.-> Rotenone["Rotenone"]
NAC -->|"inhibits"| ROS["ROS"]
NAC -.protects against.-> Neurodegeneration["Neurodegeneration"]
NAC -->|"inhibits"| Peroxidation["Peroxidation"]
NAC -->|"inhibits"| p38_MAPK["p38/MAPK"]
NAC -->|"treats"| Glaucoma["Glaucoma"]
NAC -->|"inhibits"| disulfidptosis["disulfidptosis"]
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| NAC
APOPTOSIS["APOPTOSIS"] -->|"activates"| NAC
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| NAC
TNF["TNF"] -->|"activates"| NAC
ERK["ERK"] -->|"activates"| NAC
JNK["JNK"] -->|"activates"| NAC| Target | Relation | Type | Str |
|---|---|---|---|
| Rotenone | protects_against | compound | 0.90 |
| ROS | inhibits | process | 0.90 |
| ferroptosis | inhibits | mechanism | 0.90 |
| Ros | inhibits | process | 0.90 |
| Neurodegeneration | protects_against | process | 0.85 |
| Peroxidation | inhibits | process | 0.82 |
| p38/MAPK | inhibits | pathway | 0.80 |
| Glaucoma | treats | disease | 0.75 |
| Glaucoma | treats | disease | 0.70 |
| MAPK | inhibits | pathway | 0.70 |
| lipid peroxidation | prevents | mechanism | 0.70 |
| GSH levels | activates | process | 0.70 |
| disulfidptosis | inhibits | process | 0.70 |
| NEURODEGENERATION | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| P38 | associated_with | gene | 0.45 |
| NUCLEUS ACCUMBENS | associated_with | brain_region | 0.45 |
| ROS | associated_with | phenotype | 0.45 |
| TNF | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | activates | process | 0.50 |
| APOPTOSIS | activates | process | 0.50 |
| FERROPTOSIS | activates | process | 0.50 |
| TNF | activates | gene | 0.50 |
| ERK | activates | gene | 0.50 |
| JNK | activates | gene | 0.50 |
| N-ACETYLCYSTEINE | associated_with | drug | 0.45 |
| APOPTOSIS | associated_with | phenotype | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| DEFEROXAMINE | associated_with | drug | 0.45 |
| FERROPTOSIS | associated_with | phenotype | 0.45 |
| ERK | associated_with | gene | 0.45 |
| JNK | associated_with | gene | 0.45 |
| HYPERTENSION | associated_with | disease | 0.45 |
| MAPK | associated_with | gene | 0.45 |
| MAPK PATHWAY | associated_with | pathway | 0.45 |
| GLIOSIS | associated_with | phenotype | 0.45 |
| GLAUCOMA | associated_with | disease | 0.45 |
| ANXIETY | associated_with | disease | 0.45 |
| ASTROCYTES | associated_with | cell_type | 0.45 |
| DEPRESSION | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f | 0.760 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
| X-Linked KDM6A Escapes X-Inactivation to Drive Female-Biased | 0.675 | alzheimer | Sex-Specific Microglial States in Amyloi |
| NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosi | 0.530 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
| Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple | 0.487 | neurodegeneration | How do pathological stress granules in n |
| O-GlcNAcylation at T212 competes with phosphorylation to red | 0.380 | alzheimers-disease-and-related-tauopathies | How can ESCRT or SNARE targeting achieve |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.838
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TRIM21 E3 ubiquitin ligase screen for stress granule regulation | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning NAC in their description or question text
No additional research found