SciDEX — Inflammatory Bowel Disease

graph TD
    Inflammatory_Bowel_Disease["<b>Inflammatory Bowel Disease</b>"]
    Inflammation{"Inflammation"}
    Inflammatory_Bowel_Disease -->|"activates"| Inflammation
    Als{"Als"}
    Inflammatory_Bowel_Disease -->|"therapeutic_target"| Als
    Microbiota["Microbiota"]
    Inflammatory_Bowel_Disease -->|"activates"| Microbiota
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"associated_with"| Inflammatory_Bowel_Disease
    Ulcerative_Colitis{"Ulcerative Colitis"}
    Ulcerative_Colitis -->|"associated_with"| Inflammatory_Bowel_Disease
    CANCER(["CANCER"])
    CANCER -->|"associated_with"| Inflammatory_Bowel_Disease
    style Inflammatory_Bowel_Disease fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (121)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Inflammation	associated_with	disease	0.95
Als	therapeutic_target	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Colitis-Associated Colon Cancer	risk_factor_for	disease	0.90
Microbiota	activates	pathway	0.90
Microbiota	therapeutic_target	pathway	0.80
Pi3K/Akt	treats	pathway	0.80
Microbiota	regulates	pathway	0.80
Autophagy	activates	pathway	0.80
Inflammation	contributes_to	disease	0.75
Als	regulates	disease	0.75
Inflammation	regulates	disease	0.75
Oxidative Stress	therapeutic_target	pathway	0.70
Mapk	treats	pathway	0.70
Mapk	inhibits	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Dysbiosis	activates	pathway	0.70
Inflammasome	activates	pathway	0.70
Crohn Disease	therapeutic_target	disease	0.65
Inflammation	treats	disease	0.65
Als	treats	disease	0.65
Inflammation	inhibits	disease	0.65
Psoriasis	activates	disease	0.65
Inflammation	implicated_in	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Notch	treats	pathway	0.60
Immune Response	treats	pathway	0.60
Jak-Stat	activates	pathway	0.60
Differentiation	activates	pathway	0.60
Mitochondrial Function	causes	pathway	0.60
Mitophagy	causes	pathway	0.60
Interferon Signaling	causes	pathway	0.60
Autophagy	implicated_in	pathway	0.60
Mitophagy	contributes_to	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Pyroptosis	therapeutic_target	pathway	0.60
Inflammasome	therapeutic_target	pathway	0.60
Ampk Signaling	therapeutic_target	pathway	0.60
Necroptosis	contributes_to	pathway	0.60
Mitophagy	treats	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mitochondrial Function	associated_with	pathway	0.60
Microbiota	associated_with	pathway	0.60
Chaperone	associated_with	pathway	0.60
Complement	therapeutic_target	pathway	0.60

Incoming (347)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	1.00
Ulcerative Colitis	associated_with	disease	1.00
INFLAMMATION	activates	gene	1.00
CANCER	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
PI3K	treats	gene	0.95
CYTOKINES	therapeutic_target	gene	0.95
IL10	protects_against	entity	0.90
AUTOPHAGY	suppresses	process	0.90
CANCER	activates	gene	0.85
CANCER	therapeutic_target	gene	0.85
AKT	treats	gene	0.85
GENES	activates	gene	0.85
INFLAMMATION	contributes_to	gene	0.85
AUTOPHAGY	activates	gene	0.85
Colorectal Cancer	associated_with	disease	0.85
Diabetes	associated_with	disease	0.85
INFLAMMATION	regulates	gene	0.85
Gallic Acid	protects_against	compound	0.85
NAMPT	upregulates	gene	0.85
Autophagy	protects_against	process	0.80
Ros	contributes_to	compound	0.80
Circadian Disruption	promotes	phenotype	0.80
Cancer	activates	disease	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
GENES	therapeutic_target	gene	0.75
Cancer	therapeutic_target	disease	0.75
JAK	treats	gene	0.75
INFLAMMATION	treats	gene	0.75
Ulcerative Colitis	therapeutic_target	disease	0.75
TNF	inhibits	gene	0.75
NF-ΚB	inhibits	gene	0.75
INFLAMMATION	inhibits	gene	0.75
Tumor	activates	disease	0.75
AMPK	therapeutic_target	gene	0.75
AUTOPHAGY	therapeutic_target	gene	0.75
P62	activates	gene	0.75
OXIDATIVE STRESS	associated_with	gene	0.75
Rheumatoid Arthritis	associated_with	disease	0.75
STAT3	treats	gene	0.75
P53	activates	gene	0.75
UBIQUITIN	activates	gene	0.75
IL-6	treats	gene	0.75
DNA	associated_with	gene	0.75
Akkermansia muciniphila	protects_against	compound	0.75
Hydroxytyrosol	treats	compound	0.75
Betulinic Acid	treats	chemical	0.70
Colorectal Cancer	activates	disease	0.65
NATURAL COMPOUNDS	therapeutic_target	gene	0.65

Associated Genes	INFLAMMATION, PINK1, MITOPHAGY, MTDNA, GENES, CGAS, STING, CGAS-STING
Therapeutic Agents	Hydroxytyrosol
KG Connections	451 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Inflammatory Bowel Disease

Understanding Entity Pages

Wiki Pages (20)

Gut-Brain Axis in Neurodegeneration

Multiple Sclerosis (MS)

Gut-Microbiome-Neurodegeneration Axis

LRRK2 G2019S

Melanotrophs

Pathway Diagram

Outgoing (121)

Incoming (347)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

Inflammatory Bowel Disease

Understanding Entity Pages

Wiki Pages (20)

Gut-Brain Axis in Neurodegeneration

Multiple Sclerosis (MS)

Gut-Microbiome-Neurodegeneration Axis

LRRK2 G2019S

Melanotrophs

IL28B (Interleukin 28B)

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Litronesib (LY317615/Enzastaurin)

IL32

IL3 (Interleukin 3)

Neuroinflammation in Alzheimer and Parkinson Disease

IL17C Gene

Microbiome Gut-Brain Axis Therapy

enteric-glia

can-fite-biopharma

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

Section 159: Microbiome Sequencing and Personalized Probiotics in CBS/PSP

Triggering Receptor Expressed on Myeloid Cells 3 (TREM3)

IL20 (Interleukin 20)

Acarbose Modulation of Alpha-Synuclein Amyloid Fibrillation

Pathway Diagram

Outgoing (121)

Incoming (347)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)