| Gene Symbol | METTL3 |
| Aliases | m6A Methyltransferase |
| Function | METTL3 (Methyltransferase Like 3) is the catalytic core component of the N6-methyladenosine (m6A) methyltransferase complex. |
| Subcellular Localization | </strong> Nucleus, cytosol</div>
<div class="infobox-row"><strong>Protein Fami |
| Molecular Weight | 64.6 kDa |
| Pathways | Autophagy, Akt, Pi3K, Wnt, Complement |
| GeneCards | METTL3 |
| Human Protein Atlas | METTL3 |
| m6A RNA Modification | Catalyzes N6-methyladenosine (m6A) formation, the most abundant internal modification in mRNA, affecting RNA splicing, stability, translation, and subcellular localization |
| Synaptic Transmission | m6A modification regulates the translation of synaptic proteins and controls synaptic plasticity; Mettl3 knockout in neurons leads to impaired long-term memory formation |
| Neurodevelopment | Essential for cortical neurogenesis; deletion in neural progenitor cells causes delayed neuronal differentiation and migration defects |
| Axon Guidance | Regulates the translation of axon guidance molecule mRNAs during development |
| Glial Function | Important for oligodendrocyte differentiation and myelination; m6A regulates myelin gene expression |
| Small Molecule Inhibitors | STM2457 is a selective METTL3 catalytic inhibitor that has shown promise in cancer models and is being explored for neurological applications |
| Antisense Oligonucleotides | ASOs targeting specific m6A-modified transcripts could restore normal RNA metabolism |
| Associated Diseases | ALS, Aging, Alzheimer's disease, Cancer, Ftd |
| Known Drugs/Compounds | metformin, levodopa |
| Interactions | PPARGC1A, ACSL5, BAMBI, FERROPTOSIS, CANCER, GENES |
| KG Connections | 392 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |