| Gene Symbol | NR1D1 |
| Full Name | Nuclear Receptor Subfamily 1 Group D Member 1 (REV-ERBα) |
| Chromosome | 17q11.2. |
| Protein Type | Receptor |
| Function | NR1D1 (REV-ERBα) is a nuclear receptor and transcriptional repressor that is a key component of the circadian clock. |
| Primary Expression | most tissues with circadian oscillation |
| Pathways | Circadian Rhythm, Oxidative Stress |
| UniProt ID | [Q9UH73](https://www.uniprot.org/uniprot/Q9UH73) |
| Ensembl ID | ENSG00000156395 |
| GeneCards | NR1D1 |
| Human Protein Atlas | NR1D1 |
| Circadian disruption | AD patients commonly exhibit circadian rhythm disturbances |
| Amyloid metabolism | REV-ERB regulates genes involved in amyloid precursor protein (APP) processing |
| Neuroinflammation | NR1D1 modulates inflammatory responses in the brain |
| Evidence | Circadian clock genes show altered expression in PD substantia nigra[@musiek2020] |
| Associated Diseases | Aging, Als, autism spectrum disorder, Inflammation, Migraine |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, CD68, CLOCK, CXCL1, IL4 |
| KG Connections | 124 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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