protein

CD68

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD68: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

688Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CD68 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 214 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	CD68
Full Name	Cluster of Differentiation 68
Aliases	Macrosialin
Chromosome	17p13.1
Function	CD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expression	monocytes and macrophages
Amino Acids	22 aa
Pathways	Glial Phagocytosis
NCBI Gene ID	968
Ensembl ID	ENSG00000129226
OMIM	609453
GeneCards	CD68
Human Protein Atlas	CD68
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, cancer
Interactions	ABCA1, ACSL4, Actin, AGING, AIF1, AKT
KG Connections	688 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD68 Gene

gene · 576 words

→

CD68 Protein (Macrosialin)

protein · 675 words

→

Pathway Diagram

graph TD
    CD68["CD68"]
    CD68 -.biomarker for.-> Cancer["Cancer"]
    CD68 -.biomarker for.-> Als["Als"]
    CD68 -.biomarker for.-> Inflammation["Inflammation"]
    CD68 -.biomarker for.-> Aging["Aging"]
    CD68 -.biomarker for.-> Ms["Ms"]
    CD68 -->|"expressed in"| Tumor["Tumor"]
    CD68 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    MMP9["MMP9"] -.biomarker for.-> CD68
    S100A8["S100A8"] -->|"expressed in"| CD68
    CD47["CD47"] -->|"inhibits"| CD68
    GFAP["GFAP"] -->|"expressed in"| CD68
    TNF["TNF"] -->|"inhibits"| CD68
    TLR4["TLR4"] -->|"inhibits"| CD68
    CASP3["CASP3"] -->|"expressed in"| CD68
    ANXA1["ANXA1"] -->|"expressed in"| CD68
    CGAS["CGAS"] -->|"activates"| CD68

Outgoing (422)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
macrophage activation	biomarker_for	process	0.85
Glial Phagocytosis	involved_in	process	0.80
macrophages	expressed_in	cell_type	0.80
IL-10	activates	gene	0.75
Inflammation	activates	disease	0.75
Sarcopenia	biomarker_for	disease	0.75
Als	activates	disease	0.75
oxidative stress response	participates_in	pathway	0.70
Mtor	activates	pathway	0.70
Ferroptosis	activates	pathway	0.70
Microglial inflammation	biomarker_for	mechanism	0.70
Nf-Κb	inhibits	pathway	0.70
MTOR	activates	gene	0.70
Apoptosis	inhibits	pathway	0.70
microglial inflammation	biomarker_for	phenotype	0.70
ALS	biomarker_for	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
DAM microglia	expressed_in	cell_type	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Atherosclerosis	activates	disease	0.65
Cancer	associated_with	disease	0.65
Als	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Anxiety	regulates	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Glomerulonephritis	activates	disease	0.65
Diabetes	activates	disease	0.65
Obesity	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Osteoarthritis	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Epilepsy	associated_with	disease	0.65
Lupus	activates	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Osteoarthritis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
GFAP	activates	gene	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
MACROPHAGES	interacts_with	cell_type	0.65

Incoming (266)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
MICROGLIA	associated_with	cell_type	0.72
NRF2	inhibits	gene	0.70
BAX	inhibits	gene	0.70
NF-ΚB	inhibits	gene	0.70
ROS	inhibits	gene	0.70
ALZHEIMER'S DISEASE	associated_with	disease	0.66
MICROGLIA	activates	gene	0.66
TNF	associated_with	gene	0.66
IL-6	associated_with	gene	0.66
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
P38	inhibits	gene	0.60
STAT3	therapeutic_target	gene	0.60
CD163	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
AND	activates	gene	0.60
SIRT1	expressed_in	gene	0.60
JNK	inhibits	gene	0.60
IL-1	activates	gene	0.60
ANXIETY	regulates	gene	0.60
GENES	regulates	gene	0.60
SYNAPTIC PRUNING	regulates	gene	0.60
INOS	biomarker_for	gene	0.60
RNA	therapeutic_target	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
ALS	associated_with	gene	0.60
MMP2/MMP9	inhibits	gene	0.60
CHI3L1	inhibits	gene	0.60
CD36	associated_with	gene	0.60
ACTB	regulates	gene	0.60
ADAM10	regulates	gene	0.60
AIF1	regulates	gene	0.60
APOE	regulates	gene	0.60
APP	regulates	gene	0.60
BDNF	regulates	gene	0.60
BECN1	regulates	gene	0.60
STROKE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
IL-6	inhibits	gene	0.60
CIRCADIAN RHYTHM	activates	gene	0.60
RNA	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
ARG1	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
LC3	activates	gene	0.60
KLF4	activates	gene	0.60
BNIP3	activates	gene	0.60
CD163	phosphorylates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

scRNA-seq Processing and Cell Type Annotation of AD Brain

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Can standardized scRNA-seq processing and automated annotation identify novel ce

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does the hybrid DAM + interferon-response microglial population represent a nove

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CD68 in their description or question text

No additional research found