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Home / Wiki / Project: Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD)

project 1,671 words KG: AD 2026-03-22

kind:project section:projects state:published

Contents

Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD)

Knowledge Graph

Related Hypotheses (30)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66 Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52 SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 APOE Isoform Expression Across Glial Subtypes
Score: 0.48 Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.46 Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44 HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44 LRP1-Dependent Tau Uptake Disruption
Score: 0.44 Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43 VCP-Mediated Autophagy Enhancement
Score: 0.41 Extracellular Vesicle Biogenesis Modulation
Score: 0.34 Synaptic Vesicle Tau Capture Inhibition
Score: 0.34 Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri
Score: 0.51 Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47 Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42 Prime Editing Precision Correction of APOE4 to APOE3 in Micr
Score: 0.62 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59 PARP1 Inhibition Therapy
Score: 0.58 Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57 Competitive APOE4 Domain Stabilization Peptides
Score: 0.56 Blood-Brain Barrier SPM Shuttle System
Score: 0.55 Circadian Clock-Autophagy Synchronization
Score: 0.55 Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (30)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Which cell types show the most significant expression change
neurodegeneration · completed

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · completed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · completed How do neurodegeneration gene expression patterns in SEA-AD
neurodegeneration · failed SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzh
neurodegeneration · completed How do neurodegeneration gene expression patterns in SEA-AD
neurodegeneration · archived Mechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed Do these mechanistic hypotheses from the SEA-AD Atlas bundle
neurodegeneration · failed Which cell-type vulnerability signatures from SEA-AD single-
systems biology · failed Which specific cell types show greatest vulnerability in AD
neurodegeneration · failed SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzh
neurodegeneration · archived TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40 Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95 CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90 s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40 Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40 AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40 AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40 Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40 Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40 Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40 Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40 ApoE4 Function in Alzheimer's Disease
validation · proposed · Score: 0.40 Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40 Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40 Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40 Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40 tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40 Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.40 Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated
clinical · proposed · Score: 0.40 Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · proposed · Score: 0.40 Cholinergic System Dysfunction in DLB — Mechanisms and Thera
clinical · proposed · Score: 0.40 Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40 Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40 FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation
clinical · proposed · Score: 0.40 Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40 Lifestyle Intervention Mechanisms in Alzheimer's Disease
validation · proposed · Score: 0.40 Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40 Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40 Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypotheses Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses

Sporadic Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses Sleep and Circadian Dysfunction in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Sex-Specific Mechanisms in Alzheimer's Disease
mechanism · Pages share 18 hypotheses NLRP3 Inflammasome Pathway in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Neurovascular Dysfunction in Alzheimer's Disease: Integ
mechanism · Pages share 18 hypotheses Neuroinflammation Hypothesis in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Neuroinflammation in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Mitochondrial Dysfunction in Alzheimer's Disease Pathwa
mechanism · Pages share 18 hypotheses Metal Ion Homeostasis in Alzheimer's Disease
mechanism · Pages share 18 hypotheses Locus Coeruleus Degeneration in Alzheimer's Disease
mechanism · Pages share 18 hypotheses

Knowledge Graph (12 edges)

AD causes neurodegeneration

AD inhibits cholinergic_transmission

AD causes memory_loss

AD associated_with TAU

AD regulates PROTEOME

AD associated_with GLYCOLYTIC_PATHWAY

AD causes IMMUNE_TOL

AD causes DEMENTIA

AD associated_with CHOLINERGIC_TRANSMISSION

TAU associated_with AD

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