gene 2,173 words KG: MCL1 2026-03-27
kind:genesection:genesstate:publishedtopic:mcl1topic:apoptosistopic:bcl2-familytopic:mitochondriatopic:neurodegenerationtopic:alzheimertopic:parkinson
Contents

MCL1 Gene - Myeloid Cell Leukemia 1

🧬 Gene Info
Gene SymbolMCL1
Full NameMyeloid Cell Leukemia 1
Chromosome1q21.2
Functionencodes a critical anti-apoptotic protein of the BCL2 family that plays essential roles in regulating mitochondrial outer membrane permeabilization (MOMP), cellular survival, and mitochondrial dyna...
Molecular Weight37 kDa
Amino Acids350 aa
PathwaysNF-κB
UniProt ID[Q07820](https://www.uniprot.org/uniprot/Q07820)
Ensembl IDENSG00000143384
GeneCardsMCL1
Human Protein AtlasMCL1
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
InteractionsBOK, VEGFA, SMARCA4, SF3B1, APOB, TERT
KG Connections320 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

MCL1 inhibits MDM4
MCL1 inhibits MET
MCL1 expressed_in BCL2
MCL1 expressed_in BCL2L1
MCL1 therapeutic_target VEGFA
MCL1 therapeutic_target MET
MCL1 interacts_with BOK
MCL1 therapeutic_target BAX
MCL1 associated_with MYC
MCL1 regulates APP