Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CP |
| Aliases | Page for CP Gene |
| Chromosome | 3q24 |
| Protein Type | Enzyme |
| Function | Copper transport, iron metabolism, ferroxidase activity |
| Primary Expression | liver, brain (astrocytes), and other tissues |
| Molecular Weight | 151 kDa |
| Amino Acids | 1049 aa |
| GeneCards | CP |
| Human Protein Atlas | CP |
| Protein | Ceruloplasmin |
| Related Diseases | Parkinson's Disease, Aceruloplasminemia, Alzheimer's Disease |
| Associated Diseases | Parkinson's disease, neurodegenerative_disorders |
| Interactions | CRH, PDGFRB, HDAC2, DCAF17, FA2H, FTL |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CP["<b>CP</b>"]
copper["copper"]
CP -->|"binds"| copper
IDEDNIK_syndrome{"IDEDNIK_syndrome"}
CP -->|"biomarker for"| IDEDNIK_syndrome
Wilson_s_disease{"Wilson's_disease"}
CP -->|"biomarker for"| Wilson_s_disease
ATP7A["ATP7A"]
CP -->|"interacts with"| ATP7A
ATP7B["ATP7B"]
CP -->|"interacts with"| ATP7B
neurodegenerative_disorders{"neurodegenerative_disorders"}
CP -->|"associated with"| neurodegenerative_disorders
neurodegeneration["neurodegeneration"]
CP -->|"implicated in"| neurodegeneration
style CP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| iron-dependent ferroptosis | suppresses | process | 0.90 |
| copper | binds | chemical | 0.80 |
| IDEDNIK_syndrome | biomarker_for | disease | 0.80 |
| Wilson's_disease | biomarker_for | disease | 0.80 |
| ATP7A | interacts_with | protein | 0.70 |
| ATP7B | interacts_with | protein | 0.70 |
| neurodegenerative_disorders | associated_with | disease | 0.60 |
| IR | associated_with | gene | 0.60 |
| CRH | inhibits | gene | 0.60 |
| PDGFRB | inhibits | gene | 0.60 |
| HDAC2 | activates | gene | 0.60 |
| HDAC2 | regulates | gene | 0.60 |
| HDAC2 | inhibits | gene | 0.60 |
| DCAF17 | interacts_with | gene | 0.60 |
| FA2H | interacts_with | gene | 0.60 |
| FTL | interacts_with | gene | 0.60 |
| PANK2 | interacts_with | gene | 0.60 |
| PLA2G6 | interacts_with | gene | 0.60 |
| WDR45 | interacts_with | gene | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| FLT3 | inhibits | gene | 0.60 |
| GABA | inhibits | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VCP-Mediated Autophagy Enhancement | 0.415 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257] | Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze | International journal of biolo | 2026 | 0 |
| TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849] | Camilleri JM, Zhang J, Wang T, Ahmad I, | Autophagy reports | 2026 | 0 |
| Ocular delivery of different valosin-containing protein (VCP) inhibitory formula [PMID:41617017] | Cao B, Almansa-Garcia AC, Sen M, Mühlfri | J Control Release | 2026 | 0 |
| STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. [PMID:41964371] | Lin JY, Huang ZB, Fang EF, Lu G | Autophagy | 2026 | 0 |
| Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mu [PMID:41909749] | Wang H, Jiang F, Pan A, Jin C, Xue Y, Li | Acta pharmaceutica Sinica. B | 2026 | 0 |
| Diagnostic performance of transcutaneous laryngeal ultrasound for vocal cord par [PMID:41134433] | Luo X, Xiong J, Liang S, Jiang Z, Chen H | Esophagus : official journal o | 2026 | 0 |
| The vital role of p97/valosin-containing protein-mediated degradation pathways i [PMID:41780115] | Phyu SM, Loh JXY, Zhao Y, Ramadan K | Current opinion in cell biolog | 2026 | 0 |
| STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [PMID:41903135] | Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng | Cell reports | 2026 | 0 |
| Nerve injury and vocal cord paralysis after esophageal atresia and tracheoesopha [PMID:41242420] | Soyer T, Akinci SM, Pişiren B, Arslan UE | Journal of pediatric surgery | 2026 | 0 |
| Valosin-Containing Protein as a therapeutic target in CAG repeat-driven Spinocer [PMID:41435767] | Singh S, Joshi D, Makani J, Singh S, Yad | Computational biology and chem | 2026 | 0 |
| Semi-automated Analysis of Beading in Degenerating Axons. [PMID:40272653] | ["V C P", "Pullarkat P"] | Neuroinformatics | 2025 | 0 |
| Vernix Caseosa Peritonitis: A Scoping Review. [PMID:41155773] | Augustin G, Herman M, Hrgović Z, Krešo A | Medicina (Kaunas, Lithuania) | 2025 | 0 |
| VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy. [PMID:38762759] | ["Wang Z", "Xiong S", "Wu Z", "Wang X", | Autophagy | 2024 | 0 |
| Neurodegenerative Disease Tauopathies. [PMID:37832941] | ["Creekmore B", "Watanabe R", "Lee E"] | Annual review of pathology | 2024 | 0 |
| Mitochondria ROS and mitophagy in acute kidney injury. [PMID:35678504] | ["Su L", "Zhang J", "Gomez H", "Kellum J | Autophagy | 2023 | 0 |