protein 657 words KG: ATP1A1 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

ATP1A1 Protein

🔬 Protein Info
Gene SymbolATP1A1
Full NameATPase Na+/K+ Transporting Subunit Alpha 1
Chromosome1p13.1
FunctionATP1A1 encodes the alpha-1 subunit of Na+/K+ ATPase.
Primary Expressionmost cell types including neurons, astrocytes, and oligodendrocytes
Subcellular Localization</th><td>Plasma membrane</td></tr>
Molecular Weight112 kDa
Amino Acids1000 aa
PathwaysApoptosis, Immune Response
UniProt ID[P05023](https://www.uniprot.org/uniprotkb/P05023/entry)
GeneCardsATP1A1
Human Protein AtlasATP1A1
Associated DiseasesAging, Als, Cardiovascular, Ms
KG Connections29 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (11)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: contributes_to
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
RAGE Gene
gene · KG edge: associated_with
RAB11B - RAB11B
gene · KG edge: regulates

Knowledge Graph (12 edges)

ATP1A1 regulates RAB11B
ATP1A1 regulates AMBRA1
ATP1A1 regulates SORT1
ATP1A1 contributes_to PRDX6
ATP1A1 contributes_to YWHAZ
ATP1A1 contributes_to MAPK14
ATP1A1 contributes_to LMNA
ATP1A1 associated_with RAGE
ATP1A1 regulates APOPTOSIS
ATP1A1 regulates Ms