gene 2,449 words KG: PRDX6
Contents

PRDX6 Gene

🧬 Gene Info
Gene SymbolPRDX6
Full NamePeroxiredoxin 6
Chromosome1q25.1
Functionis a unique member of the peroxiredoxin family with distinctive dual enzyme activities that set it apart from other peroxiredoxins.
Primary ExpressionBrain, Liver, Lung, Heart, Kidney
Molecular Weight25 kDa
Amino Acids224 aa
Exons9
PathwaysMitophagy
UniProt IDP30041
NCBI Gene ID9588
Ensembl IDENSG00000119004
OMIM603351
GeneCardsPRDX6
Human Protein AtlasPRDX6
Associated DiseasesAging, Als, Cancer, Cardiovascular, Ms, Tumor
InteractionsMAPK14, BECN1, TNF, ECSIT, MAP3K7, TLR4
KG Connections214 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.40

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
CLU — Clusterin (Apolipoprotein J)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PRDX6 activates MAPK14
PRDX6 activates BECN1
PRDX6 activates TNF
PRDX6 activates ECSIT
PRDX6 activates MAP3K7
PRDX6 activates TLR4
PRDX6 activates RELA
PRDX6 activates TAK1
PRDX6 activates IKBKB
PRDX6 activates IL6