gene 1,381 words KG: MAPK14
Contents

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

🧬 Gene Info
Gene SymbolMAPK14
Full NameMitogen-Activated Protein Kinase 14 (p38α)
Chromosome6p21.3
Protein TypeSerine/Threonine Kinase
Functionis a serine/threonine kinase belonging to the MAPK family.
Molecular Weight41 kDa
Amino Acids360 aa
PathwaysMAPK, TGF-β
UniProt ID[Q16539](https://www.uniprot.org/uniprot/Q16539)
Ensembl IDENSG00000166401
OMIM600289
GeneCardsMAPK14
Human Protein AtlasMAPK14
Associated DiseasesAging, Als, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/CompoundsLosmapimod, rapamycin
InteractionsBECN1, ATF6, DDIT3, NBR1, HSP70, TFE3
KG Connections740 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

p38α Inhibitor and PRMT1 Activator Combination to Restore Ph
Score: 0.61
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.46

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
APC Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MAPK14 interacts_with BECN1
MAPK14 interacts_with ATF6
MAPK14 interacts_with DDIT3
MAPK14 interacts_with NBR1
MAPK14 interacts_with HSP70
MAPK14 interacts_with TFE3
MAPK14 interacts_with MAP1LC3A
MAPK14 interacts_with MLKL
MAPK14 interacts_with DEPTOR
MAPK14 interacts_with HMGB1