protein 3,061 words KG: BECLIN1PROTEIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Beclin-1 Protein

🔬 Protein Info
Gene SymbolBECN1
Full NameBeclin-1
Chromosome17q21
FunctionBECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Molecular Weight~60 kDa
PathwaysAkt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt IDQ144X6
NCBI Gene ID8678
Ensembl IDENSG00000126581
GeneCardsBECN1
Human Protein AtlasBECN1
Protein ClassAutophagy protein
Protein Length450 amino acids
VPS34PI3K complex
VPS15Scaffold
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
Known Drugs/CompoundsRAPAMYCIN, SORAFENIB, nicotine, crocin, HCQ, rapamycin
InteractionsC9ORF72, NBR1, G3BP1, TOLLIP, SQSTM1, NDP52
KG Connections2944 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses