Contents

BRG1 Protein

🔬 Protein Info

Gene Symbol	BRG1 (SMARCA4)
Full Name	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin
Chromosome	19q13.2
Function	SMARCA4 encodes the central ATPase of the SWI/SNF complex.
Primary Expression	neural progenitors, increases with differentiation
Subcellular Localization	** \| Nucleus (chromatin-associated) \|
Molecular Weight	185 kDa
Pathways	Epigenetic
UniProt ID	P51532
NCBI Gene ID	6597
Ensembl ID	ENSG00000127616
OMIM	603254
N-terminal domain	Protein interaction motifs, including Bromo domain
ATPase domain	SNF2-type helicase domain with two RecA-like lobes
HSA domain	Actin-binding region
Associated Diseases	Cancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor
Known Drugs/Compounds	rapamycin
Interactions	AKT, ASC, ATG, BECLIN1, BECN1, BMAL1
KG Connections	229 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph