| Gene Symbol | CHRNA7 |
| Aliases | CHRNA7PROTEIN |
| Chromosome | 15q13.3 |
| Protein Type | Channel |
| Target Class | Protein |
| Function | The nicotinic acetylcholine receptor alpha 7 (α7 nAChR) is a homomeric ligand-gated ion channel highly expressed in the brain, particularly in the hippocampus, cortex, and basal ganglia. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication |
| Primary Expression | the brain, particularly in the hippocampus, cortex, and basal ganglia |
| Subcellular Localization | </th><td>Plasma Membrane</td></tr> |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase II |
| Amino Acids | 502 aa |
| Exons | 10 |
| Pathways | NF-κB, MAPK |
| Ensembl ID | ENSG00000175344 |
| GeneCards | CHRNA7 |
| Human Protein Atlas | CHRNA7 |
| Associated Diseases | ALS, Alzheimer, COLORECTAL CANCER, DNA METHYLATION, INFLAMMATION |
| Known Drugs/Compounds | valproic acid |
| Interactions | NLRP3, PI3K, JAK2, PICK1, ERK1, YAP1 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Enhancing Vagal Cholinergic Signaling to Restore G Cholinergic Attention Modulation Hypothesis |
| KG Connections | 407 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |