protein 664 words KG: CRY1
Contents

CRY1 Protein

🔬 Protein Info
Gene SymbolCRY1
Full NameCryptochrome Circadian Regulator 1
Chromosome12q24.31
FunctionTranscriptional Activation: CLOCK and BMAL1 proteins form a heterodimer that activates transcription of period (PER) and cryptochrome (CRY) genes
Primary ExpressionUbiquitous (high in brain, liver, retina)
Subcellular Localization</strong></td><td>Nucleus (primary), Cytoplasm</td></tr>
Molecular Weight66 kDa
Amino Acids500 aa
PathwaysAkt, Circadian Rhythm, Lipid Metabolism, Mtor, Nf-Κb
UniProt IDQ9UQL6
NCBI Gene ID1399
Ensembl IDENSG00000012048
OMIM601033
GeneCardsCRY1
Human Protein AtlasCRY1
Associated DiseasesAls, Depression, Stroke
InteractionsAKT, AMPK, AND, ANXIETY, App, APP
KG Connections221 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72

Related Analyses (7)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

Circadian gene expression effects of SD vs ketamine
exploratory · proposed · Score: 0.95
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

CRY1 regulates BMAL1
CRY1 regulates ARNT
CRY1 regulates TNF
CRY1 activates TNFRSF1A
CRY1 regulates OCLN
CRY1 activates ICAM1
TNF regulates CRY1
CRY1 regulates CRY2
CRY1 expressed_in CRY2
ARNT regulates CRY1

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