protein 1,001 words KG: CTNNB1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

CTNNB1 Protein

🔬 Protein Info
Gene SymbolCTNNB1
Full NameCatenin Beta 1
Chromosome3p22.1
Primary ExpressionUbiquitous, highest in brain
Subcellular LocalizationCytoplasm, nucleus, cell membrane, synapses
Molecular Weight85 kDa
Amino Acids781 aa
PathwaysWnt signaling, Wnt, Wnt pathway
UniProt IDP35222
NCBI Gene ID1499
Ensembl IDENSG00000100994
OMIM116806
GeneCardsCTNNB1
Human Protein AtlasCTNNB1
ProteinInteraction
Associated DiseasesAls, Alzheimer, Blood-Brain Barrier Integrity, Breast Cancer, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsTP53, TERT, PI3K, AKT, ANO1, ATG7
SciDEX HypothesesWnt/β-catenin Pathway Restoration
KG Connections506 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Inhibitory Neuron-Selective WNT Signaling Restoration
Score: 0.39
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 4 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses