| Gene Symbol | DDC |
| Aliases | DDCPROTEIN |
| Chromosome | 7p12.2 |
| Protein Type | Enzyme |
| Function | This is critical for PD treatment, as the efficacy of L-DOPA therapy depends on residual AADC activity in surviving nigrostriatal neurons[@lerner2020]. |
| Primary Expression | the substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus, and raphe nuclei—regions critical for movement control, rewar |
| Molecular Weight | 54 kDa |
| Amino Acids | 466 aa |
| Pathways | NF-kB signaling, circadian regulation, glymphatic clearance, oxidative stress response |
| Ensembl ID | ENSG00000132437 |
| GeneCards | DDC |
| Human Protein Atlas | DDC |
| Molecular weight | ~54 kDa |
| Primary structure | 480 amino acids |
| Cofactor requirement | Pyridoxal 5'-phosphate (PLP, vitamin B6) |
| Associated Diseases | als, alzheimer, Alzheimer's disease, dementia, huntington, ms |
| Known Drugs/Compounds | levodopa |
| Interactions | APOE, AQP4, GBA, LRRK2, MT1, SNCA |
| SciDEX Hypotheses | Correcting Gut Microbial Dopamine Imbalance to Sup |
| KG Connections | 113 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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