gene

HUNTINGTON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3682Connections
0Hypotheses
2Analyses
50Outgoing
50Incoming

Summary

HUNTINGTON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 908 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHUNTINGTON
Associated DiseasesALS, Aging, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN
InteractionsATG12, CALCINEURIN, GENES, AGING, NEURODEGENERATION, ATG10
KG Connections2350 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

Novel Therapy Index

idea · 10647 words

Parkinson's Disease

disease · 8807 words

Parthanatos in Neurodegeneration

mechanism · 6619 words

calcium-dysregulation-comparison

mechanism · 6468 words

Therapeutics

index · 5665 words

Pathway Diagram

graph TD
    HUNTINGTON["HUNTINGTON"] -->|"associated"| LYSOSOME["LYSOSOME"]
    HUNTINGTON["HUNTINGTON"] -->|"associated"| SIRT1["SIRT1"]
    HUNTINGTON["HUNTINGTON"] -->|"associated"| ALS["ALS"]
    HUNTINGTON["HUNTINGTON"] -->|"associated"| Huntington["Huntington"]
    HUNTINGTON["HUNTINGTON"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    HUNTINGTON["HUNTINGTON"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ASTROCYTE["ASTROCYTE"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
    AMPK["AMPK"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
    APP["APP"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
    BDNF["BDNF"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
    style HUNTINGTON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1829)

TargetRelationTypeStr
AMYOTROPHIC LATERAL SCLEROSISassociated_withgene1.00
Huntingtonassociated_withdisease1.00
Amyotrophic Lateral Sclerosisassociated_withdisease1.00
Parkinsonassociated_withdisease1.00
Neurodegenerationactivatesdisease1.00

Incoming (1853)

SourceRelationTypeStr
ALSassociated_withgene1.00
ALZHEIMER'S DISEASEassociated_withgene1.00
PARKINSON'S DISEASEassociated_withgene1.00
NEURODEGENERATIONregulatesgene1.00
NEURODEGENERATIONassociated_withgene1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found