Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Alzheimer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Alzheimer's disease is the most common cause of dementia, affecting over 55 million people worldwide. It is characterized by progressive memory loss, cognitive decline, and behavioral changes. Pathological hallmarks include amyloid-beta plaques, neurofibrillary tau tangles, synaptic loss, and neuroinflammation. Key risk factors include age, APOE4 genotype, cardiovascular disease, and metabolic dysfunction.
| Dentate Gyrus (DG) | Input layer, pattern separation |
| Hippocampus proper (Cornu Ammonis) | CA1, CA2, CA3 regions |
| Subiculum | Output structure |
| Entorhinal Cortex (EC) | Primary input/output interface |
| Parahippocampal cortex | Downstream processing |
| Associated Genes | CD2AP, TGM2, MIRO1, LRP1, LDLR, MAOB, GABRA1, CHAT |
| KG Connections | 5895 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
Alzheimer["Alzheimer"] -->|"activates"| Complement["Complement"]
Alzheimer["Alzheimer"] -->|"activates"| Epigenetic["Epigenetic"]
APOE_2["APOE"] -->|"activates"| Alzheimer["Alzheimer"]
TREM2["TREM2"] -->|"regulates"| Alzheimer["Alzheimer"]
MTOR["MTOR"] -->|"activates"| Alzheimer["Alzheimer"]
LC3["LC3"] -->|"activates"| Alzheimer["Alzheimer"]
end
subgraph Pathology["Pathology"]
Alzheimer["Alzheimer"] -->|"associated with"| Senescence["Senescence"]
Alzheimer["Alzheimer"] -->|"associated with"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
Alzheimer["Alzheimer"] -->|"associated with"| Lipid_Metabolism["Lipid Metabolism"]
Alzheimer["Alzheimer"] -->|"associated with"| Oxidative_Stress["Oxidative Stress"]
Alzheimer["Alzheimer"] -->|"associated with"| Neurodegeneration["Neurodegeneration"]
APOE_1["APOE"] -->|"associated with"| Alzheimer["Alzheimer"]
end
subgraph Therapeutic["Therapeutic"]
Alzheimer["Alzheimer"] -->|"therapeutic target"| Immune_Response["Immune Response"]
Alzheimer["Alzheimer"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
APOE["APOE"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
end
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Complement fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Senescence fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Immune_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Complement | activates | pathway | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Lipid Metabolism | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Lipid Metabolism | therapeutic_target | pathway | 1.00 |
| Blood-Brain Barrier | associated_with | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Mtor | associated_with | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Mitophagy | therapeutic_target | pathway | 1.00 |
| Synaptic Plasticity | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Synaptic Plasticity | therapeutic_target | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Blood-Brain Barrier | activates | pathway | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Blood-Brain Barrier | implicated_in | pathway | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Stem Cell | activates | pathway | 1.00 |
| Microbiota | regulates | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Apoptosis | implicated_in | pathway | 1.00 |
| Dementia | activates | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | therapeutic_target | gene | 1.00 |
| APOE | associated_with | gene | 1.00 |
| APOE | activates | gene | 1.00 |
| TREM2 | regulates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| OVERVIEW | associated_with | gene | 1.00 |
| TREM2 | activates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| TREM2 | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| APP | activates | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| NFL | biomarker_for | gene | 1.00 |
| APP | therapeutic_target | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| APOE | regulates | gene | 1.00 |
| TREM2 | therapeutic_target | gene | 1.00 |
| APOE | expressed_in | gene | 1.00 |
| TREM2 | expressed_in | gene | 1.00 |
| TREM2 | implicated_in | entity | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Depression | associated_with | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| APOE4 | expressed_in | gene | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| AKT | regulates | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| APOE4 | associated_with | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| Tauopathy | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| DNA | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] | Vadalà A, Benelli C, Suraci F, Carta B, | Arch Orthop Trauma Surg | 2026 | 0 |
| Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] | Yang S, Wang X, Yan Y, Zhang J, Wei Y et | J Affect Disord | 2026 | 0 |
| Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610] | Gelot AB, Draia-Nicolau TO, Mathieu R, S | Epilepsia | 2025 | 0 |
| Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783] | Guan M, Xie Y, Wang Z, Miao Y, Li X et a | Transl Psychiatry | 2025 | 0 |
| Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068] | Zhang C, Xie Z, Wang N | Am J Transl Res | 2025 | 0 |
| Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] | Bershteyn M, Zhou H, Fuentealba L, Chen | Neuron | 2025 | 0 |
| Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704] | Hunker AC, Wirthlin ME, Gill G, Johansen | Neuron | 2025 | 0 |
| Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] | Walsh RM, Crabtree GW, Kalpana K, Jubier | Neuron | 2025 | 0 |
| Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404] | Qi C, Sima W, Mao H, Hu E, Ge J et al. | Nat Commun | 2025 | 0 |
| Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329] | Morabito A, Zerlaut Y, Dhanasobhon D, Be | Neuron | 2025 | 0 |
| Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040] | Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK | Autophagy | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nat Neurosci | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J et a | Front Immunol | 2024 | 0 |
| Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373] | Fisher J, Verhagen M, Long Z, Moissidis | Neuron | 2024 | 0 |
| Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473] | Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a | Adv Sci (Weinh) | 2024 | 0 |
| Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] | Almeida VN | Ageing Res Rev | 2024 | 0 |
| Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213] | Mòdol L, Moissidis M, Selten M, Oozeer F | Neuron | 2024 | 0 |
| De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258] | Tang S, Conte V, Zhang DJ, Žedaveinytė R | Science | 2024 | 0 |
| Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669] | Lee BR, Dalley R, Miller JA, Chartrand T | Science | 2023 | 0 |
| Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868] | Xia D, Lianoglou S, Sandmann T, Calvert | Mol Neurodegener | 2022 | 0 |