protein 1,788 words KG: DOT1LPROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

DOT1L Protein

🔬 Protein Info
Gene SymbolDOT1L
Full NameHistone H3K79 Methyltransferase
AliasesDisruptor of Telomeric Silencing 1-like
Protein TypeTransferase
Functionencodes a protein of 1,670 amino acids with methyltransferase activity that is conserved from yeast to humans [2](https://pubmed.
Subcellular Localization</strong></td><td>Nucleus (chromatin-associated)</td></tr>
Molecular Weight190 kDa
Amino Acids670 aa
PathwaysCalcium Signaling, Epigenetic, Hedgehog, Nf-Κb, Toll-Like Receptor
Ensembl IDENSG00000100811
GeneCardsDOT1L
Human Protein AtlasDOT1L
Associated DiseasesAD, Chemoresistance, Ms, OVARIAN CANCER, Ovarian Carcinoma
InteractionsPARP1, NLRP3, CANCER, Raf, Ras, App
KG Connections129 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph