protein

GSDMD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSDMD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

880Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

GSDMD is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 220 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GSDMD
Full Name	GSDMD (Gasdermin D)
Chromosome	8p22
Function	is a gene encoding a key executor of pyroptotic cell death
Primary Expression	hippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight	56 kDa
Amino Acids	484 aa
Pathways	Apoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
UniProt ID	Q8NHS0
NCBI Gene ID	79792
Ensembl ID	ENSG00000104534
GeneCards	GSDMD
Human Protein Atlas	GSDMD
Official Symbol	GSDMD
Strategy	Approach
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Cancer, Cardiovascular
Known Drugs/Compounds	curcumin, natural products, Qingqi Liangying Formula, XHP, Pterostilbene
Interactions	SCD1, HMGCR, TNF, MLKL, ACSL4, MYD88
KG Connections	880 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSDMD["GSDMD"]
    GSDMD -->|"activates"| pyroptosis["pyroptosis"]
    GSDMD -->|"inhibits"| Inflammation["Inflammation"]
    GSDMD -->|"inhibits"| Hepatitis["Hepatitis"]
    GSDMD -->|"inhibits"| Fibrosis["Fibrosis"]
    GSDMD -->|"activates"| Als["Als"]
    GSDMD -->|"activates"| Parkinson["Parkinson"]
    GSDMD -->|"activates"| Stroke["Stroke"]
    GSDMD -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GSDMD -->|"activates"| Ms["Ms"]
    NLRP3["NLRP3"] -->|"activates"| GSDMD
    PYROPTOSIS["PYROPTOSIS"] -->|"regulates"| GSDMD
    FASN["FASN"] -->|"inhibits"| GSDMD
    BAX["BAX"] -->|"inhibits"| GSDMD
    ALOX15["ALOX15"] -->|"inhibits"| GSDMD
    POLE["POLE"] -->|"activates"| GSDMD
    TREM2["TREM2"] -->|"activates"| GSDMD
    TLR4["TLR4"] -->|"activates"| GSDMD
    ACSL4["ACSL4"] -->|"inhibits"| GSDMD
    TNF["TNF"] -->|"inhibits"| GSDMD

Outgoing (591)

Target	Relation	Type	Str
microglial pyroptosis	promotes	process	0.95
Astrocytic Pyroptosis	mediates	process	0.95
Pyroptosis	mediates	process	0.95
pyroptosis	mediates	process	0.95
pyroptosis	drives	process	0.95
pyroptosis	promotes	process	0.92
Microglial Pyroptosis	mediates	process	0.90
neurodegeneration	promotes	process	0.90
Membrane Rupture	mediates	process	0.90
pyroptosis	participates_in	pathway	0.90
autism spectrum disorder	interacts_with	disease	0.90
Fibrosis	contributes_to	disease	0.90
Inflammation	activates	disease	0.85
Pyroptosis	involved_in	process	0.85
Depression	involved_in	disease	0.85
autism	regulates	disease	0.80
autism	activates	disease	0.80
autism	inhibits	disease	0.80
oxidative stress response	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80
autism spectrum disorder	activates	disease	0.80
pyroptosis	inhibits	process	0.80
unfolded protein response	participates_in	pathway	0.80
Alzheimer's disease	implicated_in	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
NLRP3	activates	gene	0.80
Pyroptosis	inhibits	pathway	0.80
ROS	activates	gene	0.80
Als	activates	disease	0.75
Neuroinflammation	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
STING	activates	gene	0.70
NLRP3	inhibits	gene	0.70
NLRP3	degrades	gene	0.70
autism	degrades	disease	0.70
neuroinflammation	interacts_with	disease	0.70
Ferroptosis	inhibits	pathway	0.70
Nf-Κb	activates	pathway	0.70
pyroptosis	activates	process	0.70
INFLAMMATION	activates	gene	0.70
Pyroptosis	activates	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
MTDNA	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
MITOPHAGY	activates	gene	0.70
Mitophagy	activates	pathway	0.70
PYROPTOSIS	inhibits	gene	0.70
NEUROTOXICITY	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70

Incoming (289)

Source	Relation	Type	Str
caspase-1	cleaves	protein	0.95
CASP1	activates	gene	0.95
Qingqi Liangying Formula	inhibits	drug	0.95
XHP	activates	drug	0.95
NLRP3	activates	gene	0.90
CASP1	associated_with	protein	0.90
TLR2	upregulates	gene	0.90
NLRP3 inflammasome	activates	protein	0.90
CASP1	phosphorylates	protein	0.90
Pterostilbene	inhibits	compound	0.90
Microglia	expressed_in	cell_type	0.90
Astrocytes	expressed_in	cell_type	0.90
Neuron	expressed_in	cell_type	0.90
Aucubin	downregulates	compound	0.89
NLRP3	upstream_of	protein	0.88
Tlr2 Inhibition	suppresses	mechanism	0.85
natural products	targets	compound	0.75
ACSL4	inhibits	gene	0.70
PYROPTOSIS	regulates	pathway	0.64
FASN	inhibits	gene	0.60
BAX	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
POLE	activates	gene	0.60
TREM2	activates	gene	0.60
TLR4	activates	gene	0.60
TNF	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
MYD88	activates	gene	0.60
BAX	activates	gene	0.60
DRP1	activates	gene	0.60
FADD	activates	gene	0.60
NRF2	activates	gene	0.60
ABCG2	activates	gene	0.60
ZBP1	activates	gene	0.60
MFN2	activates	gene	0.60
ZBP1	inhibits	gene	0.60
RAB7A	activates	gene	0.60
VDAC1	activates	gene	0.60
DRP1	regulates	gene	0.60
MMP9	therapeutic_target	gene	0.60
CASP8	therapeutic_target	gene	0.60
MLKL	inhibits	gene	0.60
IBA1	associated_with	gene	0.60
GPX4	regulates	gene	0.60
PINK1	activates	gene	0.60
GPX4	inhibits	gene	0.60
BAX	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
NLRP3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSDMD

Understanding Entity Pages

Summary

Wiki Pages (21)

GSDMD Gene

Novel Therapy Index

Blood-Brain Barrier Biology and Crossing Strategies

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

ASC (PYCARD)

nlrp3-inflammasome

LRRK2 — Leucine Rich Repeat Kinase 2

NLRP3 Inflammasome Hypothesis in Parkinson's Disease

Pyroptosis

Necroptosis in Alzheimer's Disease

casp8

Neuroinflammatory Cytokine Storm in Neurodegeneration

Pyroptosis in Neurodegeneration

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

Neuroinflammation in PD

GSDME — Gasdermin E

CNTF Gene

CASP1 Gene

pyroptosis-signaling-pathway-neurodegeneration