protein 2,656 words KG: DYNACTIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Dynactin Protein

🔬 Protein Info
Gene SymbolDYNACTIN
Protein FamilyDynactin family
FunctionDynein alone exhibits relatively short "runs" along microtubule tracks, typically moving only 0.5-1 μm before dissociating [13].
Subcellular Localization</strong></td><td>Cytoplasm, microtubules</td></tr> [@levy2006]
Molecular Weight150 kDa
PathwaysAxonal Transport, Autophagy, Cholesterol
UniProt IDQ14203
GeneCardsDYNACTIN
Human Protein AtlasDYNACTIN
Associated Diseasesneurodegeneration
InteractionsDYNEIN, LDLR, RAB7, POLE, DCTN1, Dynein
KG Connections41 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Lysosomal Positioning Dynamics Modulation
Score: 0.43
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Dynein Motor Protein
mechanism · KG edge: activates
Axonal Transport
mechanism · KG edge: transports
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
LDLR Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

DYNACTIN interacts_with DYNEIN
DYNACTIN transports Axonal Transport
DYNACTIN activates LDLR
DYNACTIN interacts_with RAB7
DYNACTIN co_discussed DYNEIN
DYNACTIN activates DYNEIN
DYNACTIN activates POLE
DYNACTIN activates DCTN1
DYNACTIN regulates DNAJB6
DYNACTIN activates Dynein