protein

DYNEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

309Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

DYNEIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, causes, transports. Associated with ALS, Alzheimer, Tumor. Connected to 76 entities in the SciDEX knowledge graph.

View on Wiki →

🔬 Protein Info
Gene SymbolDYNEIN
Full NameDynein — Cytoplasmic Dynein 1
AliasesCytoplasmic Dynein 1
Protein TypeProtein
FunctionDynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies
Molecular Weight500 kDa
PathwaysAutophagy, Pyroptosis
UniProt IDSearch UniProt
GeneCardsDYNEIN
Human Protein AtlasDYNEIN
Tail domainThe N-terminal tail (~200 kDa) mediates heavy chain dimerization and cargo binding through interaction with intermediate chains.
Associated DiseasesALS, Parkinson's Disease, disease
InteractionsLMNA, DHCR24, DAPK1, IL1B, FAS, EIF2AK2
KG Connections230 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: DYNEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Dynein Motor Protein

mechanism · 2466 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Novel Therapy Index

idea · 10647 words

NTF4 Protein

protein · 5111 words

Mitochondrial Quality Control

mechanism · 5069 words

HNRNPA2B1 Protein

protein · 5015 words

Pathway Diagram

graph TD
    DYNEIN["<b>DYNEIN</b>"]
    ALS{"ALS"}
    DYNEIN -->|"causes"| ALS
    Tumor{"Tumor"}
    DYNEIN -->|"interacts with"| Tumor
    DYNEIN -->|"interacts with"| ALS
    Alzheimer{"Alzheimer"}
    DYNEIN -->|"interacts with"| Alzheimer
    MICROTUBULES["MICROTUBULES"]
    DYNEIN -->|"interacts with"| MICROTUBULES
    PAFAH1B1["PAFAH1B1"]
    DYNEIN -->|"causes"| PAFAH1B1
    DAB1["DAB1"]
    DYNEIN -->|"causes"| DAB1
    REELIN["REELIN"]
    DYNEIN -->|"causes"| REELIN
    LMNA["LMNA"]
    DYNEIN -->|"interacts with"| LMNA
    Amyloid(["Amyloid"])
    DYNEIN -->|"interacts with"| Amyloid
    Apoptosis(["Apoptosis"])
    DYNEIN -->|"interacts with"| Apoptosis
    Axonal_Transport(["Axonal Transport"])
    DYNEIN -->|"transports"| Axonal_Transport
    CDK5["CDK5"]
    CDK5 -->|"causes"| DYNEIN
    AXON["AXON"]
    AXON -->|"causes"| DYNEIN
    LIS1["LIS1"]
    LIS1 -->|"interacts with"| DYNEIN
    NEURON["NEURON"]
    NEURON -->|"causes"| DYNEIN
    DCX["DCX"]
    DCX -->|"causes"| DYNEIN
    MAPT["MAPT"]
    MAPT -->|"associated with"| DYNEIN
    DNA["DNA"]
    DNA -->|"interacts with"| DYNEIN
    A2M["A2M"]
    A2M -->|"interacts with"| DYNEIN
    APOE["APOE"]
    APOE -->|"interacts with"| DYNEIN
    PSEN2["PSEN2"]
    PSEN2 -->|"interacts with"| DYNEIN
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"interacts with"| DYNEIN
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"interacts with"| DYNEIN
    style DYNEIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (165)

TargetRelationTypeStr
ALScausesdisease0.65
Tumorinteracts_withdisease0.65
ALSinteracts_withdisease0.65
Alzheimerinteracts_withdisease0.65
Cancerinteracts_withdisease0.65

Incoming (144)

SourceRelationTypeStr
CDK5causesgene0.60
LIS1interacts_withgene0.60
DCXcausesgene0.60
MAPTassociated_withgene0.60
A2Minteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found