Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DYNEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DYNEIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, causes, transports. Associated with ALS, Alzheimer, Tumor. Connected to 76 entities in the SciDEX knowledge graph.
| Gene Symbol | DYNEIN |
| Full Name | Dynein — Cytoplasmic Dynein 1 |
| Aliases | Cytoplasmic Dynein 1 |
| Protein Type | Protein |
| Function | Dynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies |
| Molecular Weight | 500 kDa |
| Pathways | Autophagy, Pyroptosis |
| UniProt ID | Search UniProt |
| GeneCards | DYNEIN |
| Human Protein Atlas | DYNEIN |
| Tail domain | The N-terminal tail (~200 kDa) mediates heavy chain dimerization and cargo binding through interaction with intermediate chains. |
| Associated Diseases | ALS, Parkinson's Disease, disease |
| Interactions | LMNA, DHCR24, DAPK1, IL1B, FAS, EIF2AK2 |
| KG Connections | 230 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DYNEIN["<b>DYNEIN</b>"]
ALS{"ALS"}
DYNEIN -->|"causes"| ALS
Tumor{"Tumor"}
DYNEIN -->|"interacts with"| Tumor
DYNEIN -->|"interacts with"| ALS
Alzheimer{"Alzheimer"}
DYNEIN -->|"interacts with"| Alzheimer
MICROTUBULES["MICROTUBULES"]
DYNEIN -->|"interacts with"| MICROTUBULES
PAFAH1B1["PAFAH1B1"]
DYNEIN -->|"causes"| PAFAH1B1
DAB1["DAB1"]
DYNEIN -->|"causes"| DAB1
REELIN["REELIN"]
DYNEIN -->|"causes"| REELIN
LMNA["LMNA"]
DYNEIN -->|"interacts with"| LMNA
Amyloid(["Amyloid"])
DYNEIN -->|"interacts with"| Amyloid
Apoptosis(["Apoptosis"])
DYNEIN -->|"interacts with"| Apoptosis
Axonal_Transport(["Axonal Transport"])
DYNEIN -->|"transports"| Axonal_Transport
CDK5["CDK5"]
CDK5 -->|"causes"| DYNEIN
AXON["AXON"]
AXON -->|"causes"| DYNEIN
LIS1["LIS1"]
LIS1 -->|"interacts with"| DYNEIN
NEURON["NEURON"]
NEURON -->|"causes"| DYNEIN
DCX["DCX"]
DCX -->|"causes"| DYNEIN
MAPT["MAPT"]
MAPT -->|"associated with"| DYNEIN
DNA["DNA"]
DNA -->|"interacts with"| DYNEIN
A2M["A2M"]
A2M -->|"interacts with"| DYNEIN
APOE["APOE"]
APOE -->|"interacts with"| DYNEIN
PSEN2["PSEN2"]
PSEN2 -->|"interacts with"| DYNEIN
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
MITOCHONDRIAL_DNA -->|"interacts with"| DYNEIN
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"interacts with"| DYNEIN
style DYNEIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | causes | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Parkinson | contributes_to | disease | 0.65 |
| Huntington | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Bipolar | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Neuropathy | transports | disease | 0.65 |
| Neurodegeneration | transports | disease | 0.65 |
| Huntington | transports | disease | 0.65 |
| PAFAH1B1 | causes | gene | 0.60 |
| DAB1 | causes | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| Axonal Transport | transports | pathway | 0.60 |
| DHCR24 | interacts_with | gene | 0.60 |
| DAPK1 | interacts_with | gene | 0.60 |
| IL1B | interacts_with | gene | 0.60 |
| FAS | interacts_with | gene | 0.60 |
| EIF2AK2 | interacts_with | gene | 0.60 |
| IL6 | interacts_with | gene | 0.60 |
| PSEN2 | interacts_with | gene | 0.60 |
| A2M | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| PSEN1 | interacts_with | gene | 0.60 |
| APH1B | interacts_with | gene | 0.60 |
| NCSTN | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| HSPG2 | interacts_with | gene | 0.60 |
| PEN2 | interacts_with | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| RILP | interacts_with | gene | 0.60 |
| DYNACTIN | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CDK5 | causes | gene | 0.60 |
| LIS1 | interacts_with | gene | 0.60 |
| DCX | causes | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| A2M | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| PSEN2 | interacts_with | gene | 0.60 |
| NCSTN | interacts_with | gene | 0.60 |
| APH1B | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| IL1B | interacts_with | gene | 0.60 |
| DHCR24 | interacts_with | gene | 0.60 |
| FAS | interacts_with | gene | 0.60 |
| PSEN1 | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| PEN2 | interacts_with | gene | 0.60 |
| DAPK1 | interacts_with | gene | 0.60 |
| IL6 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| EIF2AK2 | interacts_with | gene | 0.60 |
| HMGCR | interacts_with | gene | 0.60 |
| HSPG2 | interacts_with | gene | 0.60 |
| DYNACTIN | interacts_with | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| DAB1 | causes | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| DNAJB6 | regulates | gene | 0.60 |
| DYNACTIN | activates | gene | 0.60 |
| PINK1 | contributes_to | gene | 0.60 |
| OPA1 | expressed_in | gene | 0.60 |
| RHOT1 | activates | gene | 0.60 |
| DCTN1 | activates | gene | 0.60 |
| PAFAH1B1 | causes | gene | 0.60 |
| PARKIN | contributes_to | gene | 0.60 |
| TRKA | transports | gene | 0.60 |
| RET | transports | gene | 0.60 |
| MAP1B | transports | gene | 0.60 |
| TAU | transports | gene | 0.60 |
| BDNF | transports | gene | 0.60 |
| HTT | transports | gene | 0.60 |
| APP | transports | gene | 0.60 |
| HUNTINGTIN | transports | gene | 0.60 |
| AXON | causes | gene | 0.60 |
| NEURON | causes | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| MITOCHONDRIAL DNA | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| AMYLOID | interacts_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||