Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DCTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DCTN1 |
| Full Name | Dynactin Subunit 1 (p150^Glued) |
| Aliases | Dynactin subunit p150^Glued |
| Protein Family | Dynactin complex |
| Function | DCTN1 plays critical roles in neuronal function |
| Subcellular Localization | Cytoplasm, neuronal axons, growth cones |
| Molecular Weight | 150 kDa |
| Amino Acids | 238 aa |
| UniProt ID | Q14203 |
| GeneCards | DCTN1 |
| Human Protein Atlas | DCTN1 |
| Mutation | Phenotype |
| p.P56L | Perry syndrome |
| p.G59E | Perry syndrome/PD |
| p.R155C | Perry syndrome |
| Associated Diseases | ALS, frontotemporal dementia |
| Interactions | DYNEIN, DYNACTIN, POLE, Dynein, LAMP2, MAP1LC3B |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DCTN1["DCTN1"]
DCTN1 -->|"activates"| Als["Als"]
DCTN1 -->|"activates"| ALS["ALS"]
DCTN1 -->|"regulates"| Bipolar["Bipolar"]
DCTN1 -->|"activates"| DYNEIN["DYNEIN"]
DCTN1 -->|"activates"| AND["AND"]
DCTN1 -->|"activates"| DYNACTIN["DYNACTIN"]
DCTN1 -->|"activates"| POLE["POLE"]
DCTN1 -->|"regulates"| DNAJB6["DNAJB6"]
DNAJB6 -->|"regulates"| DCTN1
DYNACTIN -->|"activates"| DCTN1
DYNEIN -->|"activates"| DCTN1
POLE -->|"activates"| DCTN1| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.70 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Bipolar | regulates | disease | 0.65 |
| DYNEIN | activates | gene | 0.60 |
| DYNACTIN | activates | gene | 0.60 |
| POLE | activates | gene | 0.60 |
| DNAJB6 | regulates | gene | 0.60 |
| Dynein | activates | protein | 0.60 |
| FIG4 | associated_with | gene | 0.60 |
| FUS | associated_with | gene | 0.60 |
| NEFH | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| SPG11 | associated_with | gene | 0.60 |
| TAF15 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| VAPB | associated_with | gene | 0.60 |
| VCP | associated_with | gene | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Actin | activates | protein | 0.60 |
| frontotemporal dementia | associated_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| LC3B | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||