protein 629 words KG: DYNEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Dynein — Cytoplasmic Dynein 1

🔬 Protein Info
Gene SymbolDYNEIN
Full NameDynein — Cytoplasmic Dynein 1
AliasesCytoplasmic Dynein 1
Protein TypeProtein
FunctionDynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies
Subcellular Localizationthe microtubule-organizing center near the cell body). The complex comprises multiple subunits with distinct functional
Molecular Weight500 kDa
PathwaysAutophagy, Pyroptosis
UniProt IDSearch UniProt
GeneCardsDYNEIN
Human Protein AtlasDYNEIN
Associated DiseasesALS, Parkinson's Disease, disease
InteractionsLMNA, DHCR24, DAPK1, IL1B, FAS, EIF2AK2
KG Connections230 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

See Also (10)

Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
APH1B Gene - Anterior Pharynx Defective 1 Homolog B
gene · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

DYNEIN interacts_with LIS1
DYNEIN interacts_with MAPT
DYNEIN causes PAFAH1B1
DYNEIN causes DAB1
DYNEIN causes REELIN
DYNEIN interacts_with LMNA
DYNEIN transports Axonal Transport
DYNEIN interacts_with DHCR24
DYNEIN interacts_with DAPK1
DYNEIN interacts_with IL1B