protein 876 words KG: REELIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Reelin Protein

🔬 Protein Info
Gene SymbolRELN
AliasesComprehensive page on Reelin
Chromosome7q22.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight388 kDa
Amino Acids460 aa
PathwaysDendritic Spine
UniProt IDP78536
NCBI Gene ID5649
GeneCardsRELN
Human Protein AtlasRELN
ApproachStatus
Recombinant Reelin proteinResearch
Reelin-enhancing compoundsPreclinical
Gene therapyPreclinical
Associated DiseasesALS, AUTISM, Aging, Alzheimer, Alzheimer'S Disease
InteractionsCD2AP, REST, MTOR, CCR5, CCL5, CXCR4
KG Connections322 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target

Knowledge Graph (12 edges)

REELIN regulates Dendritic Spine
REELIN associated_with LRP1B
REELIN causes DCX
REELIN causes CDK5
REELIN causes LIS1
REELIN causes DYNEIN
REELIN causes DAB1
REELIN causes PAFAH1B1
REELIN activates CD2AP
REELIN activates REST