gene 1,687 words KG: A2M
Contents

A2M Gene

🧬 Gene Info
Gene SymbolA2M
Chromosome12p13.31 (human)
Protein Familyα2-macroglobulin family
FunctionThe protein possesses a unique "trap" mechanism
Molecular Weight~720 kDa (tetramer)
Amino Acids1450 amino acids
UniProt IDP01023
NCBI Gene ID2
GeneCardsA2M
Human Protein AtlasA2M
ProteinAlpha-2-macroglobulin
SynonymsA2MP, alpha-2-M, α2M
Protein Length1450 amino acids
ApproachDevelopment Stage
A2M enhancementPreclinical
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer's disease, Depression
InteractionsDHCR24, HMGCR, MAPT, PARP1, PEN2, PSEN1
KG Connections107 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (25)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Glycosaminoglycan Template Disruption Approach
Score: 0.46
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: implicated_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

A2M interacts_with DHCR24
A2M interacts_with HMGCR
A2M interacts_with MAPT
A2M interacts_with PARP1
A2M interacts_with PEN2
A2M interacts_with PSEN1
A2M interacts_with DAPK1
A2M interacts_with HSPG2
A2M interacts_with IL1B
A2M interacts_with APP