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gene 1,687 words KG: ent-gene-6d4506f6
Contents

A2M Gene

🧬 Gene Info
Gene SymbolA2M
Chromosome12p13.31 (human)
Protein Familyα2-macroglobulin family
FunctionThe protein possesses a unique "trap" mechanism
Molecular Weight~720 kDa (tetramer)
Amino Acids1450 amino acids
UniProt IDP01023
NCBI Gene ID2
GeneCardsA2M
Human Protein AtlasA2M
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI, Depression
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE, APOPTOSIS
KG Connections110 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Glycosaminoglycan Template Disruption Approach
Score: 0.60SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74
pg 1/2Next →

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_withAccelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_inAPH1B Gene - Anterior Pharynx Defective 1 Homolog B
gene · KG edge: interacts_withAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_withPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-6d4506f6 data_in benchmark_ot_ad_answer_key:A2M
benchmark_ot_ad_answer_key:A2M data_in ent-gene-6d4506f6

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