| Gene Symbol | GABA |
| Full Name | A Alpha-4 Protein |
| Chromosome | 12p12.3 |
| Function | is a hallmark of neurodegeneration. |
| Primary Expression | hippocampus, cortex, cerebellum, thalamus, hypothalamus |
| Amino Acids | 602 aa |
| Exons | 14 |
| Pathways | GABAergic Signaling |
| GeneCards | GABA |
| Human Protein Atlas | GABA |
| Extracellular N-terminal domain | Contains the benzodiazepine binding site |
| Transmembrane domains | Four transmembrane helices forming the channel pore |
| Intracellular loop | Contains sites for phosphorylation and trafficking signals |
| C-terminal domain | Important for receptor assembly and localization |
| Benzodiazepine sensitivity | Alpha-4-containing receptors have reduced benzodiazepine sensitivity |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCA7, ACTB, Actin, Akt, AKT, AKT1 |
| KG Connections | 1370 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!